Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543873114> ?p ?o ?g. }
- W1543873114 endingPage "135" @default.
- W1543873114 startingPage "45" @default.
- W1543873114 abstract "The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and compared to 44 distal bile duct and 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in the WNT signaling pathway among half of the patients and in all three adenocarcinomas irrespective of their origin and histological morphology. These tumors were characterized by a high frequency of inactivating mutations of ELF3, a high rate of microsatellite instability, and common focal deletions and amplifications, suggesting common attributes in the molecular pathogenesis are at play in these tumors. The high frequency of WNT pathway activating mutation, coupled with small-molecule inhibitors of β-catenin in clinical trials, suggests future treatment decisions for these patients may be guided by genomic analysis." @default.
- W1543873114 created "2016-06-24" @default.
- W1543873114 creator A5058167367 @default.
- W1543873114 date "1997-01-01" @default.
- W1543873114 modified "2023-10-16" @default.
- W1543873114 title "Tumor Suppressor Genes and Human Cancer" @default.
- W1543873114 cites W14762771 @default.
- W1543873114 cites W1495670687 @default.
- W1543873114 cites W1525669528 @default.
- W1543873114 cites W1554072136 @default.
- W1543873114 cites W1561926822 @default.
- W1543873114 cites W1565339590 @default.
- W1543873114 cites W1576330810 @default.
- W1543873114 cites W1591281137 @default.
- W1543873114 cites W16019424 @default.
- W1543873114 cites W1605151524 @default.
- W1543873114 cites W1648625743 @default.
- W1543873114 cites W1746080159 @default.
- W1543873114 cites W1779679253 @default.
- W1543873114 cites W183341991 @default.
- W1543873114 cites W1851856540 @default.
- W1543873114 cites W1873059808 @default.
- W1543873114 cites W1935791347 @default.
- W1543873114 cites W1944714834 @default.
- W1543873114 cites W1953331331 @default.
- W1543873114 cites W1964619416 @default.
- W1543873114 cites W1965173366 @default.
- W1543873114 cites W1966538954 @default.
- W1543873114 cites W1966552709 @default.
- W1543873114 cites W1966630774 @default.
- W1543873114 cites W1967205646 @default.
- W1543873114 cites W1967243795 @default.
- W1543873114 cites W1967588153 @default.
- W1543873114 cites W1967688669 @default.
- W1543873114 cites W1968348266 @default.
- W1543873114 cites W1969044026 @default.
- W1543873114 cites W1969881374 @default.
- W1543873114 cites W1969989752 @default.
- W1543873114 cites W1971602793 @default.
- W1543873114 cites W1972050299 @default.
- W1543873114 cites W1972404642 @default.
- W1543873114 cites W1972642770 @default.
- W1543873114 cites W1972651910 @default.
- W1543873114 cites W1973277018 @default.
- W1543873114 cites W1974010399 @default.
- W1543873114 cites W1974764716 @default.
- W1543873114 cites W1975324295 @default.
- W1543873114 cites W1975993620 @default.
- W1543873114 cites W1976936729 @default.
- W1543873114 cites W1977284533 @default.
- W1543873114 cites W1977299280 @default.
- W1543873114 cites W1977686001 @default.
- W1543873114 cites W1977706798 @default.
- W1543873114 cites W1978225718 @default.
- W1543873114 cites W1978400153 @default.
- W1543873114 cites W1978669977 @default.
- W1543873114 cites W1979618971 @default.
- W1543873114 cites W1979778268 @default.
- W1543873114 cites W1980223679 @default.
- W1543873114 cites W1980450624 @default.
- W1543873114 cites W1980847511 @default.
- W1543873114 cites W1980890490 @default.
- W1543873114 cites W1981112371 @default.
- W1543873114 cites W1981391513 @default.
- W1543873114 cites W1982361487 @default.
- W1543873114 cites W1982768428 @default.
- W1543873114 cites W1983171715 @default.
- W1543873114 cites W1983348452 @default.
- W1543873114 cites W1983892050 @default.
- W1543873114 cites W1985745152 @default.
- W1543873114 cites W1985940796 @default.
- W1543873114 cites W1986179131 @default.
- W1543873114 cites W1986812747 @default.
- W1543873114 cites W1986937402 @default.
- W1543873114 cites W1987006267 @default.
- W1543873114 cites W1987536971 @default.
- W1543873114 cites W1988848776 @default.
- W1543873114 cites W1988935612 @default.
- W1543873114 cites W1989040551 @default.
- W1543873114 cites W1989927312 @default.
- W1543873114 cites W1989970624 @default.
- W1543873114 cites W1989976890 @default.
- W1543873114 cites W1990538835 @default.
- W1543873114 cites W1990880437 @default.
- W1543873114 cites W1991727881 @default.
- W1543873114 cites W1992045438 @default.
- W1543873114 cites W1992750486 @default.
- W1543873114 cites W1993951035 @default.
- W1543873114 cites W1994840092 @default.
- W1543873114 cites W1995095999 @default.
- W1543873114 cites W1995254238 @default.
- W1543873114 cites W1995259219 @default.
- W1543873114 cites W1995574948 @default.
- W1543873114 cites W1995819860 @default.
- W1543873114 cites W1995856480 @default.
- W1543873114 cites W1996302902 @default.
- W1543873114 cites W1996413533 @default.
- W1543873114 cites W1996449685 @default.