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• W1543885024 abstract "Type 1 diabetes is an autoimmune disease that usually strikes during adolescence resulting in uncontrolled blood glucose levels. Auto-reactive T-cells target the insulin producing beta cells of the pancreas resulting in their destruction. The only treatment currently available is lifelong administration of insulin to bring blood glucose levels back under control. The identification of insulin and its mass production were the first major success in the treatment of the disease. Building on the work of others, Frederick Banting and Charles Best demonstrated the ability of insulin to maintain normoglycemia in pancreatectomized dogs in 1921 (Banting; Best; Collip, et al., 1922) and with the help of Eli Lilly the mass production of insulin was under way by 1922 for clinical use. Prior to this the disease was fatal by 3 years. No less than 4 Nobel prizes have been rewarded over the years for research on insulin’s indentification, sequence, structure, and the production of recombinant human insulin. Despite the success of insulin therapy, it is now obvious that even rigorous control of blood glucose with insulin injections only delays, but does not prevent the development of diabetic complications (The DCCT Research Group, 1993). Diabetic complications, which include cardiovascular disease, diabetic retinopathy, kidney failure, and neuropathy, account for significant diabetes-related patient morbidity and mortality. Islet transplantation has been attempted to restore the normal release patterns of insulin, but sufficient source donors are limiting, the possibility of lifelong anti-rejection drugs may prove worse than diabetes, and the autoimmune process that destroyed the original beta cells are still active (Huurman; Hilbrands; Pinkse, et al., 2008, Marzorati; PileggiR Huurman; Hilbrands, et al., 2009, Van Belle&von Herrath, 2008). Therefore therapeutics that modify the immune response and restore normal immune function are necessary to improve the outcomes of patients with type 1 diabetes. Little has changed in the primary treatment of type 1 diabetes over the last 90 years, but immunotherapy techniques hold the promise of finding a true cure." @default.
• W1543885024 created "2016-06-24" @default.
• W1543885024 creator A5001857296 @default.
• W1543885024 creator A5029419954 @default.
• W1543885024 date "2011-11-25" @default.
• W1543885024 modified "2023-10-04" @default.
• W1543885024 title "Type 1 Diabetes Immunotherapy - Successes, Failures and Promises" @default.
• W1543885024 cites W12180408 @default.
• W1543885024 cites W124239641 @default.
• W1543885024 cites W1492703726 @default.
• W1543885024 cites W1508436155 @default.
• W1543885024 cites W1511359439 @default.
• W1543885024 cites W1557849107 @default.
• W1543885024 cites W1574833715 @default.
• W1543885024 cites W159079723 @default.
• W1543885024 cites W1647776454 @default.
• W1543885024 cites W1691628240 @default.
• W1543885024 cites W176352299 @default.
• W1543885024 cites W1856161448 @default.
• W1543885024 cites W1907062065 @default.
• W1543885024 cites W1912307887 @default.
• W1543885024 cites W1929904751 @default.
• W1543885024 cites W1966657187 @default.
• W1543885024 cites W1972066210 @default.
• W1543885024 cites W1972621450 @default.
• W1543885024 cites W1975284062 @default.
• W1543885024 cites W1975579793 @default.
• W1543885024 cites W1977020088 @default.
• W1543885024 cites W1979928281 @default.
• W1543885024 cites W1980690619 @default.
• W1543885024 cites W1990180666 @default.
• W1543885024 cites W1992439632 @default.
• W1543885024 cites W1997452174 @default.
• W1543885024 cites W2004282938 @default.
• W1543885024 cites W2005923637 @default.
• W1543885024 cites W2006554521 @default.
• W1543885024 cites W2007366214 @default.
• W1543885024 cites W2008367158 @default.
• W1543885024 cites W2008373133 @default.
• W1543885024 cites W2009342458 @default.
• W1543885024 cites W2009980407 @default.
• W1543885024 cites W2018703348 @default.
• W1543885024 cites W2019661234 @default.
• W1543885024 cites W2020384794 @default.
• W1543885024 cites W2022773559 @default.
• W1543885024 cites W2024351056 @default.
• W1543885024 cites W2027516013 @default.
• W1543885024 cites W2035156103 @default.
• W1543885024 cites W2037780312 @default.
• W1543885024 cites W2039166049 @default.
• W1543885024 cites W2039414380 @default.
• W1543885024 cites W2041266914 @default.
• W1543885024 cites W2044952915 @default.
• W1543885024 cites W2045385822 @default.
• W1543885024 cites W2047627851 @default.
• W1543885024 cites W2052006922 @default.
• W1543885024 cites W2055297593 @default.
• W1543885024 cites W2055568247 @default.
• W1543885024 cites W2056088597 @default.
• W1543885024 cites W2057043713 @default.
• W1543885024 cites W2059593985 @default.
• W1543885024 cites W2064431167 @default.
• W1543885024 cites W2065127537 @default.
• W1543885024 cites W2068354564 @default.
• W1543885024 cites W2069938061 @default.
• W1543885024 cites W2070461635 @default.
• W1543885024 cites W2071756824 @default.
• W1543885024 cites W2076342192 @default.
• W1543885024 cites W2076899204 @default.
• W1543885024 cites W2079794444 @default.
• W1543885024 cites W2083147686 @default.
• W1543885024 cites W2084006363 @default.
• W1543885024 cites W2089550035 @default.
• W1543885024 cites W2090072693 @default.
• W1543885024 cites W2091429830 @default.
• W1543885024 cites W2096385412 @default.
• W1543885024 cites W2103050854 @default.
• W1543885024 cites W2104258246 @default.
• W1543885024 cites W2108072818 @default.
• W1543885024 cites W2111457140 @default.
• W1543885024 cites W2117002902 @default.
• W1543885024 cites W2117923276 @default.
• W1543885024 cites W2118600639 @default.
• W1543885024 cites W2118994799 @default.
• W1543885024 cites W2125426440 @default.
• W1543885024 cites W2125659714 @default.
• W1543885024 cites W2135280067 @default.
• W1543885024 cites W2136911983 @default.
• W1543885024 cites W2138343247 @default.
• W1543885024 cites W2139279363 @default.
• W1543885024 cites W2140066663 @default.
• W1543885024 cites W2141111992 @default.
• W1543885024 cites W2143450422 @default.
• W1543885024 cites W2152864702 @default.
• W1543885024 cites W2153644370 @default.
• W1543885024 cites W2155623284 @default.
• W1543885024 cites W2155964470 @default.
• W1543885024 cites W2156312279 @default.
• W1543885024 cites W2156694159 @default.
• W1543885024 cites W2158485667 @default.

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