FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543933515> ?p ?o ?g. }

• W1543933515 endingPage "1515" @default.
• W1543933515 startingPage "1503" @default.
• W1543933515 abstract "Dolastatin 10 is a potent antimitotic peptide isolated from the marine mollusk Dolabella auricularia. Four of its five residues are modified amino acids (in sequence, dolavaline, valine, dolaisoleuine, dolaproine, dolaphenine). Besides inhibiting tubulin polymerization, dolastatin 10 noncompetitively inhibits vinca alkaloid binding to tubulin, inhibits nucleotide exchange and formation of the βs cross-link, and stabilizes the colchicine binding activity of tubulin. To examine the mechanism of action of dolastatin 10 we prepared six chiral isomers, one tri- and one tetrapeptide segment, and one pentapeptide analog of dolastatin 10, all of which differ little from dolastatin 10 as inhibitors of tubulin polymerization. However, only two of the chiral isomers were similar to dolastatin 10 in their cytotoxicity for L1210 murine leukemia cells and in their effects on vinblastine binding, nucleotide exchange, βs cross-link formation, and colchicine binding. These were isomer 2, with reversal of configuration at position C(19a) in the dolaisoleuine moiety, and isomer 19, with reversal of configuration at position C(6) in the dolaphenine moiety. The pentapeptides with reduced cytotoxicity and reduced effects on tubulin interactions with other ligands were all modified in the dolaproine moiety at positions C(9) and/ or C(10). The tripeptide and tetrapeptide segments which inhibited polymerization but not ligand interactions were the amino terminal tripeptide (lacking dolaproine and dolaphenine) and the carboxyl terminal tetrapeptide (lacking dolavaline). We speculate that strong inhibition of other ligand interactions with tubulin requires stable peptide binding to tubulin (i.e. slow dissociation), but that inhibition of polymerization requires only rapid binding to tubulin." @default.
• W1543933515 created "2016-06-24" @default.
• W1543933515 creator A5016676831 @default.
• W1543933515 creator A5023833051 @default.
• W1543933515 creator A5060769865 @default.
• W1543933515 creator A5066809993 @default.
• W1543933515 creator A5070630405 @default.
• W1543933515 creator A5072999086 @default.
• W1543933515 creator A5088149477 @default.
• W1543933515 date "1993-04-01" @default.
• W1543933515 modified "2023-09-24" @default.
• W1543933515 title "Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin" @default.
• W1543933515 cites W1495417308 @default.
• W1543933515 cites W1497987465 @default.
• W1543933515 cites W1509684747 @default.
• W1543933515 cites W1542114385 @default.
• W1543933515 cites W1560764577 @default.
• W1543933515 cites W1569622146 @default.
• W1543933515 cites W1588010906 @default.
• W1543933515 cites W1589293594 @default.
• W1543933515 cites W1594849497 @default.
• W1543933515 cites W1885901959 @default.
• W1543933515 cites W1910209889 @default.
• W1543933515 cites W1969669189 @default.
• W1543933515 cites W1979824797 @default.
• W1543933515 cites W1980853395 @default.
• W1543933515 cites W1985009758 @default.
• W1543933515 cites W1985607495 @default.
• W1543933515 cites W1987801027 @default.
• W1543933515 cites W1989132809 @default.
• W1543933515 cites W1994162165 @default.
• W1543933515 cites W2002671248 @default.
• W1543933515 cites W2011511767 @default.
• W1543933515 cites W2017167372 @default.
• W1543933515 cites W2025008851 @default.
• W1543933515 cites W2033341314 @default.
• W1543933515 cites W2038456507 @default.
• W1543933515 cites W2040276835 @default.
• W1543933515 cites W2049262877 @default.
• W1543933515 cites W2053931073 @default.
• W1543933515 cites W2069837054 @default.
• W1543933515 cites W2086526874 @default.
• W1543933515 cites W2090009704 @default.
• W1543933515 cites W2094866078 @default.
• W1543933515 doi "https://doi.org/10.1016/0006-2952(93)90051-w" @default.
• W1543933515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8471072" @default.
• W1543933515 hasPublicationYear "1993" @default.
• W1543933515 type Work @default.
• W1543933515 sameAs 1543933515 @default.
• W1543933515 citedByCount "59" @default.
• W1543933515 countsByYear W15439335152012 @default.
• W1543933515 countsByYear W15439335152013 @default.
• W1543933515 countsByYear W15439335152014 @default.
• W1543933515 countsByYear W15439335152015 @default.
• W1543933515 countsByYear W15439335152016 @default.
• W1543933515 countsByYear W15439335152017 @default.
• W1543933515 countsByYear W15439335152018 @default.
• W1543933515 countsByYear W15439335152019 @default.
• W1543933515 countsByYear W15439335152020 @default.
• W1543933515 countsByYear W15439335152021 @default.
• W1543933515 countsByYear W15439335152022 @default.
• W1543933515 crossrefType "journal-article" @default.
• W1543933515 hasAuthorship W1543933515A5016676831 @default.
• W1543933515 hasAuthorship W1543933515A5023833051 @default.
• W1543933515 hasAuthorship W1543933515A5060769865 @default.
• W1543933515 hasAuthorship W1543933515A5066809993 @default.
• W1543933515 hasAuthorship W1543933515A5070630405 @default.
• W1543933515 hasAuthorship W1543933515A5072999086 @default.
• W1543933515 hasAuthorship W1543933515A5088149477 @default.
• W1543933515 hasConcept C116569031 @default.
• W1543933515 hasConcept C167392928 @default.
• W1543933515 hasConcept C168831097 @default.
• W1543933515 hasConcept C170493617 @default.
• W1543933515 hasConcept C185592680 @default.
• W1543933515 hasConcept C20418707 @default.
• W1543933515 hasConcept C2776568683 @default.
• W1543933515 hasConcept C2776636253 @default.
• W1543933515 hasConcept C2779281246 @default.
• W1543933515 hasConcept C2779564779 @default.
• W1543933515 hasConcept C2909592991 @default.
• W1543933515 hasConcept C45197812 @default.
• W1543933515 hasConcept C515207424 @default.
• W1543933515 hasConcept C54355233 @default.
• W1543933515 hasConcept C55493867 @default.
• W1543933515 hasConcept C71240020 @default.
• W1543933515 hasConcept C84425145 @default.
• W1543933515 hasConcept C86803240 @default.
• W1543933515 hasConcept C95444343 @default.
• W1543933515 hasConceptScore W1543933515C116569031 @default.
• W1543933515 hasConceptScore W1543933515C167392928 @default.
• W1543933515 hasConceptScore W1543933515C168831097 @default.
• W1543933515 hasConceptScore W1543933515C170493617 @default.
• W1543933515 hasConceptScore W1543933515C185592680 @default.
• W1543933515 hasConceptScore W1543933515C20418707 @default.
• W1543933515 hasConceptScore W1543933515C2776568683 @default.
• W1543933515 hasConceptScore W1543933515C2776636253 @default.
• W1543933515 hasConceptScore W1543933515C2779281246 @default.
• W1543933515 hasConceptScore W1543933515C2779564779 @default.

• next