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- W1544146715 abstract "Resorcinol derivatives, tropolones and diones, having pKa′s in the range 3–7 uncouple oxidative phosphorylation in liver mitochondria. Many substituted resorcinols and tropolones are more potent uncouplers than the related phenols and it is possible to relate this enhanced potency to their lower pKa′s than those of the corresponding phenols. Optimal uncoupling activity was observed with compounds having pKa close to 4.0 (e.g. 3, 5, 7-tribromotropolone, 2-phenyl-indan-1, 3-dione), and considerable lipophilic character. The anti-inflammatory activity of some lipophilic resorcinols and a cycloheptimidazolone drug (RCH-314) is discussed in relation to the theory that ability to uncouple oxidative phosphorylation may determine anti-inflammatory activity. Tetrabromocatechol inhibits yeast hexokinase." @default.
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- W1544146715 date "1965-04-01" @default.
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- W1544146715 title "Biochemical properties of anti-inflammatory drugs—IV" @default.
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- W1544146715 doi "https://doi.org/10.1016/0006-2952(65)90227-3" @default.
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