FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544147210> ?p ?o ?g. }

• W1544147210 endingPage "46" @default.
• W1544147210 startingPage "35" @default.
• W1544147210 abstract "Summary The td group I intron interrupting the thymidylate synthase (TS) gene of phage T4 is a mobile intron that encodes the homing endonuclease I‐TevI. Efficient RNA splicing of the intron is required to restore function of the TS gene, while expression of I‐TevI from within the intron is required to initiate intron mobility. Three distinct layers of regulation temporally limit I‐TevI expression to late in the T4 infective cycle, yet the biological rationale for stringent regulation has not been tested. Here, we deleted key control elements to deregulate I‐TevI expression at early and middle times post T4 infection. Strikingly, we found that deregulation of I‐TevI, or of a catalytically inactive variant, generated a thymidine‐dependent phenotype that is caused by a reduction in td intron splicing. Prematurely terminating I‐TevI translation restores td splicing, full‐length TS synthesis, and rescues the thymidine‐dependent phenotype. We suggest that stringent translational control of I‐TevI evolved to prevent the ribosome from disrupting key structural elements of the td intron that are required for splicing and TS function at early and middle times post T4 infection. Analogous translational regulatory mechanisms in unrelated intron‐open reading frame arrangements may also function to limit deleterious consequences on splicing and host gene function." @default.
• W1544147210 created "2016-06-24" @default.
• W1544147210 creator A5029125718 @default.
• W1544147210 creator A5052179215 @default.
• W1544147210 date "2010-05-19" @default.
• W1544147210 modified "2023-10-16" @default.
• W1544147210 title "Better late than early: delayed translation of intron-encoded endonuclease I-TevI is required for efficient splicing of its host group I intron" @default.
• W1544147210 cites W102702072 @default.
• W1544147210 cites W1158930877 @default.
• W1544147210 cites W1234770113 @default.
• W1544147210 cites W1492150736 @default.
• W1544147210 cites W1594338269 @default.
• W1544147210 cites W1689364519 @default.
• W1544147210 cites W1847209356 @default.
• W1544147210 cites W1972238996 @default.
• W1544147210 cites W1973648449 @default.
• W1544147210 cites W1975182669 @default.
• W1544147210 cites W1978201154 @default.
• W1544147210 cites W2002360525 @default.
• W1544147210 cites W2007761614 @default.
• W1544147210 cites W2008165954 @default.
• W1544147210 cites W2026858326 @default.
• W1544147210 cites W2029823040 @default.
• W1544147210 cites W2035783320 @default.
• W1544147210 cites W2050647031 @default.
• W1544147210 cites W2052115251 @default.
• W1544147210 cites W2059190205 @default.
• W1544147210 cites W2061620977 @default.
• W1544147210 cites W2067321301 @default.
• W1544147210 cites W2068422582 @default.
• W1544147210 cites W2069564138 @default.
• W1544147210 cites W2070596390 @default.
• W1544147210 cites W2077372526 @default.
• W1544147210 cites W2077785805 @default.
• W1544147210 cites W2078872641 @default.
• W1544147210 cites W2083501365 @default.
• W1544147210 cites W2084841438 @default.
• W1544147210 cites W2093417734 @default.
• W1544147210 cites W2105078181 @default.
• W1544147210 cites W2108942962 @default.
• W1544147210 cites W2109280361 @default.
• W1544147210 cites W2109952581 @default.
• W1544147210 cites W2110986352 @default.
• W1544147210 cites W2112884159 @default.
• W1544147210 cites W2120600301 @default.
• W1544147210 cites W2121919940 @default.
• W1544147210 cites W2122723902 @default.
• W1544147210 cites W2129144582 @default.
• W1544147210 cites W2130379010 @default.
• W1544147210 cites W2145237484 @default.
• W1544147210 cites W2146588737 @default.
• W1544147210 cites W2148886909 @default.
• W1544147210 cites W2163414819 @default.
• W1544147210 cites W2164720265 @default.
• W1544147210 cites W2168154114 @default.
• W1544147210 cites W222250992 @default.
• W1544147210 cites W2395549144 @default.
• W1544147210 cites W4242772314 @default.
• W1544147210 doi "https://doi.org/10.1111/j.1365-2958.2010.07216.x" @default.
• W1544147210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20497330" @default.
• W1544147210 hasPublicationYear "2010" @default.
• W1544147210 type Work @default.
• W1544147210 sameAs 1544147210 @default.
• W1544147210 citedByCount "14" @default.
• W1544147210 countsByYear W15441472102012 @default.
• W1544147210 countsByYear W15441472102013 @default.
• W1544147210 countsByYear W15441472102014 @default.
• W1544147210 countsByYear W15441472102015 @default.
• W1544147210 crossrefType "journal-article" @default.
• W1544147210 hasAuthorship W1544147210A5029125718 @default.
• W1544147210 hasAuthorship W1544147210A5052179215 @default.
• W1544147210 hasConcept C104317684 @default.
• W1544147210 hasConcept C118346598 @default.
• W1544147210 hasConcept C175817850 @default.
• W1544147210 hasConcept C2777028655 @default.
• W1544147210 hasConcept C54355233 @default.
• W1544147210 hasConcept C54458228 @default.
• W1544147210 hasConcept C64962909 @default.
• W1544147210 hasConcept C67705224 @default.
• W1544147210 hasConcept C86803240 @default.
• W1544147210 hasConcept C94671646 @default.
• W1544147210 hasConceptScore W1544147210C104317684 @default.
• W1544147210 hasConceptScore W1544147210C118346598 @default.
• W1544147210 hasConceptScore W1544147210C175817850 @default.
• W1544147210 hasConceptScore W1544147210C2777028655 @default.
• W1544147210 hasConceptScore W1544147210C54355233 @default.
• W1544147210 hasConceptScore W1544147210C54458228 @default.
• W1544147210 hasConceptScore W1544147210C64962909 @default.
• W1544147210 hasConceptScore W1544147210C67705224 @default.
• W1544147210 hasConceptScore W1544147210C86803240 @default.
• W1544147210 hasConceptScore W1544147210C94671646 @default.
• W1544147210 hasIssue "1" @default.
• W1544147210 hasLocation W15441472101 @default.
• W1544147210 hasLocation W15441472102 @default.
• W1544147210 hasOpenAccess W1544147210 @default.
• W1544147210 hasPrimaryLocation W15441472101 @default.
• W1544147210 hasRelatedWork W1760434519 @default.
• W1544147210 hasRelatedWork W1995065708 @default.

• next