FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544150251> ?p ?o ?g. }

• W1544150251 endingPage "2242" @default.
• W1544150251 startingPage "2231" @default.
• W1544150251 abstract "BACKGROUND AND PURPOSE So far, there is only limited information about the regulation of the endogenous synthesis of hydrogen sulfide (H 2 S), an important gaseous signalling molecule. This study was done to evaluate the redox‐dependent signalling events that regulate the expression of the H 2 S synthesising enzyme cystathionine‐γ‐lyase (CSE) in rat mesangial cells. EXPERIMENTAL APPROACH The effects of platelet‐derived growth factor (PDGF)‐BB and antioxidants on CSE expression and activity in cultured rat renal mesangial cells were assessed. Activity of nuclear factor erythroid‐2‐related factor‐2 (Nrf2) was measured as the binding capacity to a radiolabelled consensus element by electrophoretic mobility shift assay (EMSA). Furthermore, CSE and Nrf2 expression was analysed in a rat model of anti‐Thy‐1‐induced glomerulonephritis by immunohistochemistry. KEY RESULTS Treatment of mesangial cells with PDGF‐BB resulted in a marked time‐ and dose‐dependent up‐regulation of CSE mRNA and protein levels, as well as CSE activity accompanied with increased formation of reactive oxygen species. Remarkably, co‐administration of antioxidants, such as N‐acetylcysteine, ebselen or diphenylene iodonium chloride, drastically reduced PDGF‐BB‐induced CSE expression. PDGF‐BB induced binding of Nrf2 to a corresponding consensus antioxidant element in a redox‐dependent manner. Furthermore, PDGF‐BB‐induced CSE expression in mouse mesangial cells was completely abolished in Nrf2 knockout mice compared with wild‐type mice. In a rat model of anti‐Thy‐1‐induced proliferative glomerulonephritis, we observed a marked up‐regulation of CSE protein paralleled by a stabilization of Nrf2 protein. CONCLUSIONS AND IMPLICATIONS PDGF‐BB regulated CSE via a redox‐mediated activation of Nrf2. Such action would aid the resolution of glomerular inflammatory diseases. LINKED ARTICLE This article is commented on by Gallyas, pp. 2228–2230 of this issue. To view this commentary visit http://dx.doi.org/10.1111/j.1476‐5381.2012.01976.x" @default.
• W1544150251 created "2016-06-24" @default.
• W1544150251 creator A5000912075 @default.
• W1544150251 creator A5001384511 @default.
• W1544150251 creator A5002720012 @default.
• W1544150251 creator A5006569354 @default.
• W1544150251 creator A5007339984 @default.
• W1544150251 creator A5011279213 @default.
• W1544150251 creator A5015539308 @default.
• W1544150251 creator A5045821088 @default.
• W1544150251 creator A5074909982 @default.
• W1544150251 creator A5076283335 @default.
• W1544150251 creator A5077072888 @default.
• W1544150251 creator A5090808178 @default.
• W1544150251 date "2012-07-24" @default.
• W1544150251 modified "2023-10-18" @default.
• W1544150251 title "Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism" @default.
• W1544150251 cites W1521559784 @default.
• W1544150251 cites W1764016564 @default.
• W1544150251 cites W1913383562 @default.
• W1544150251 cites W1916800927 @default.
• W1544150251 cites W1970709922 @default.
• W1544150251 cites W1974623278 @default.
• W1544150251 cites W1980654657 @default.
• W1544150251 cites W1990488806 @default.
• W1544150251 cites W1991631628 @default.
• W1544150251 cites W1996926003 @default.
• W1544150251 cites W2004712996 @default.
• W1544150251 cites W2005050136 @default.
• W1544150251 cites W2014641242 @default.
• W1544150251 cites W2015407072 @default.
• W1544150251 cites W2016005410 @default.
• W1544150251 cites W2016457162 @default.
• W1544150251 cites W2016730049 @default.
• W1544150251 cites W2023943529 @default.
• W1544150251 cites W2028516053 @default.
• W1544150251 cites W2028666766 @default.
• W1544150251 cites W2031368441 @default.
• W1544150251 cites W2033941047 @default.
• W1544150251 cites W2037089003 @default.
• W1544150251 cites W2054064167 @default.
• W1544150251 cites W2062145087 @default.
• W1544150251 cites W2063207603 @default.
• W1544150251 cites W2068102724 @default.
• W1544150251 cites W2069380892 @default.
• W1544150251 cites W2071711321 @default.
• W1544150251 cites W2072474837 @default.
• W1544150251 cites W2072540192 @default.
• W1544150251 cites W2075740485 @default.
• W1544150251 cites W2080935518 @default.
• W1544150251 cites W2085295620 @default.
• W1544150251 cites W2088757784 @default.
• W1544150251 cites W2091307499 @default.
• W1544150251 cites W2092184603 @default.
• W1544150251 cites W2096395306 @default.
• W1544150251 cites W2101283727 @default.
• W1544150251 cites W2101516244 @default.
• W1544150251 cites W2101836733 @default.
• W1544150251 cites W2115338196 @default.
• W1544150251 cites W2121976123 @default.
• W1544150251 cites W2127065370 @default.
• W1544150251 cites W2136769507 @default.
• W1544150251 cites W2149350091 @default.
• W1544150251 cites W2152699459 @default.
• W1544150251 cites W2158366323 @default.
• W1544150251 cites W2161220011 @default.
• W1544150251 cites W2169541861 @default.
• W1544150251 cites W2170798535 @default.
• W1544150251 cites W2172161196 @default.
• W1544150251 cites W2339760129 @default.
• W1544150251 cites W2398759984 @default.
• W1544150251 doi "https://doi.org/10.1111/j.1476-5381.2012.01949.x" @default.
• W1544150251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3448890" @default.
• W1544150251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22428706" @default.
• W1544150251 hasPublicationYear "2012" @default.
• W1544150251 type Work @default.
• W1544150251 sameAs 1544150251 @default.
• W1544150251 citedByCount "39" @default.
• W1544150251 countsByYear W15441502512012 @default.
• W1544150251 countsByYear W15441502512013 @default.
• W1544150251 countsByYear W15441502512014 @default.
• W1544150251 countsByYear W15441502512015 @default.
• W1544150251 countsByYear W15441502512016 @default.
• W1544150251 countsByYear W15441502512017 @default.
• W1544150251 countsByYear W15441502512018 @default.
• W1544150251 countsByYear W15441502512019 @default.
• W1544150251 countsByYear W15441502512021 @default.
• W1544150251 countsByYear W15441502512022 @default.
• W1544150251 countsByYear W15441502512023 @default.
• W1544150251 crossrefType "journal-article" @default.
• W1544150251 hasAuthorship W1544150251A5000912075 @default.
• W1544150251 hasAuthorship W1544150251A5001384511 @default.
• W1544150251 hasAuthorship W1544150251A5002720012 @default.
• W1544150251 hasAuthorship W1544150251A5006569354 @default.
• W1544150251 hasAuthorship W1544150251A5007339984 @default.
• W1544150251 hasAuthorship W1544150251A5011279213 @default.
• W1544150251 hasAuthorship W1544150251A5015539308 @default.
• W1544150251 hasAuthorship W1544150251A5045821088 @default.

• next