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• W1544188722 startingPage "6177" @default.
• W1544188722 abstract "The Cro protein specified by bacteriophage lambda is a of the genes expressed early in phage development and is required for a normal late stage of lytic growth. We have purified Cro protein to virtual homogeneity and analyzed its structure and properties as a DNA-binding protein and of RNA synthesis. To confirm that the protein is the product of the cro gene, we have also shown that a missense mutation in the cro gene leads to a product that is more temperature- and salt-sensitive in its DNA-binding property. As purified, Cro protein is a dimer of identical subunits of molecular weight 8600. The purified protein binds to lambda-DNA carrying the specific binding sites (operators oL and oR) with an estimated dissociation constant of 10(-10) M to 10(-11) M; there is also weaker binding to other sites on DNA, as found for other DNA-binding regulatory proteins. In a purified transcription system, the Cro protein is an effective and specific of RNA synthesis from the N and cro genes; thus Cro is an autorepressor which regulates its own synthesis. A comparison of the properties of the two lambda proteins, cI and Cro, indicates that cI is a strong repressor specialized for complete turnoff of lytic functions needed for the maintenance of lysogeny, whereas Cro is a weak repressor specialized for a gradual turnoff of early viral genes that potentiates the late stage of lytic development." @default.
• W1544188722 created "2016-06-24" @default.
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• W1544188722 creator A5025770436 @default.
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• W1544188722 date "1977-09-01" @default.
• W1544188722 modified "2023-09-29" @default.
• W1544188722 title "Cro regulatory protein specified by bacteriophage lambda. Structure, DNA-binding, and repression of RNA synthesis." @default.
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• W1544188722 doi "https://doi.org/10.1016/s0021-9258(17)40047-0" @default.
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