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• W1544206819 endingPage "4172" @default.
• W1544206819 startingPage "4150" @default.
• W1544206819 abstract "Heat shock factors form a family of transcription factors (four in mammals), which were named according to the first discovery of their activation by heat shock. As a result of the universality and robustness of their response to heat shock, the stress-dependent activation of heat shock factor became a ‘paradigm’: by binding to conserved DNA sequences (heat shock elements), heat shock factors trigger the expression of genes encoding heat shock proteins that function as molecular chaperones, contributing to establish a cytoprotective state to various proteotoxic stress and in several pathological conditions. Besides their roles in the stress response, heat shock factors perform crucial roles during gametogenesis and development in physiological conditions. First, during these process, in stress conditions, they are either proactive for survival or, conversely, for apoptotic process, allowing elimination or, inversely, protection of certain cell populations in a way that prevents the formation of damaged gametes and secure future reproductive success. Second, heat shock factors display subtle interplay in a tissue- and stage-specific manner, in regulating very specific sets of heat shock genes, but also many other genes encoding growth factors or involved in cytoskeletal dynamics. Third, they act not only by their classical transcription factor activities, but are necessary for the establishment of chromatin structure and, likely, genome stability. Finally, in contrast to the heat shock gene paradigm, heat shock elements bound by heat shock factors in developmental process turn out to be extremely dispersed in the genome, which is susceptible to lead to the future definition of ‘developmental heat shock element’." @default.
• W1544206819 created "2016-06-24" @default.
• W1544206819 creator A5016521818 @default.
• W1544206819 creator A5024658242 @default.
• W1544206819 date "2010-09-23" @default.
• W1544206819 modified "2023-10-17" @default.
• W1544206819 title "Roles of heat shock factors in gametogenesis and development" @default.
• W1544206819 cites W1501901620 @default.
• W1544206819 cites W1529357822 @default.
• W1544206819 cites W1532143905 @default.
• W1544206819 cites W1555441628 @default.
• W1544206819 cites W1599209244 @default.
• W1544206819 cites W1854498651 @default.
• W1544206819 cites W1902562397 @default.
• W1544206819 cites W1914313496 @default.
• W1544206819 cites W1923734845 @default.
• W1544206819 cites W1933920814 @default.
• W1544206819 cites W1945968356 @default.
• W1544206819 cites W1951729607 @default.
• W1544206819 cites W1954249603 @default.
• W1544206819 cites W1967343219 @default.
• W1544206819 cites W1968780495 @default.
• W1544206819 cites W1975195662 @default.
• W1544206819 cites W1976254609 @default.
• W1544206819 cites W1976727208 @default.
• W1544206819 cites W1977114591 @default.
• W1544206819 cites W1977257176 @default.
• W1544206819 cites W1978904327 @default.
• W1544206819 cites W1979630995 @default.
• W1544206819 cites W1980291812 @default.
• W1544206819 cites W1980431235 @default.
• W1544206819 cites W1981276526 @default.
• W1544206819 cites W1981501274 @default.
• W1544206819 cites W1982480043 @default.
• W1544206819 cites W1985549353 @default.
• W1544206819 cites W1989996595 @default.
• W1544206819 cites W1990310057 @default.
• W1544206819 cites W1990365155 @default.
• W1544206819 cites W1990710362 @default.
• W1544206819 cites W1992624136 @default.
• W1544206819 cites W1995278409 @default.
• W1544206819 cites W1996781482 @default.
• W1544206819 cites W1997643195 @default.
• W1544206819 cites W1998096309 @default.
• W1544206819 cites W2000286622 @default.
• W1544206819 cites W2000459271 @default.
• W1544206819 cites W2008536823 @default.
• W1544206819 cites W2008746419 @default.
• W1544206819 cites W2008806314 @default.
• W1544206819 cites W2010868220 @default.
• W1544206819 cites W2011044632 @default.
• W1544206819 cites W2012995240 @default.
• W1544206819 cites W2016426012 @default.
• W1544206819 cites W2017606348 @default.
• W1544206819 cites W2018704517 @default.
• W1544206819 cites W2022501802 @default.
• W1544206819 cites W2025807591 @default.
• W1544206819 cites W2026062399 @default.
• W1544206819 cites W2027456357 @default.
• W1544206819 cites W2027619822 @default.
• W1544206819 cites W2027688801 @default.
• W1544206819 cites W2027922031 @default.
• W1544206819 cites W2031793125 @default.
• W1544206819 cites W2032840272 @default.
• W1544206819 cites W2033469836 @default.
• W1544206819 cites W2035893777 @default.
• W1544206819 cites W2036423361 @default.
• W1544206819 cites W2039813772 @default.
• W1544206819 cites W2040235353 @default.
• W1544206819 cites W2042368077 @default.
• W1544206819 cites W2042420011 @default.
• W1544206819 cites W2043622843 @default.
• W1544206819 cites W2044182000 @default.
• W1544206819 cites W2047333140 @default.
• W1544206819 cites W2047399073 @default.
• W1544206819 cites W2049382784 @default.
• W1544206819 cites W2053967200 @default.
• W1544206819 cites W2055467457 @default.
• W1544206819 cites W2055527665 @default.
• W1544206819 cites W2056103918 @default.
• W1544206819 cites W2059336217 @default.
• W1544206819 cites W2059628271 @default.
• W1544206819 cites W2062087581 @default.
• W1544206819 cites W2062848785 @default.
• W1544206819 cites W2064451353 @default.
• W1544206819 cites W2067551890 @default.
• W1544206819 cites W2068011303 @default.
• W1544206819 cites W2068073076 @default.
• W1544206819 cites W2072561392 @default.
• W1544206819 cites W2077296518 @default.
• W1544206819 cites W2078824105 @default.
• W1544206819 cites W2080893376 @default.
• W1544206819 cites W2084937865 @default.
• W1544206819 cites W2085112773 @default.
• W1544206819 cites W2089418549 @default.
• W1544206819 cites W2089742961 @default.
• W1544206819 cites W2089744025 @default.
• W1544206819 cites W2090174984 @default.

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