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- W1544248596 abstract "Objective: To identify the abnormal chemosensitivity-associated DNA methylation pattern of CpG islands in the promoter region of breast cancer cell lines and provide the evidence for using abnormal DNA methylation in predicting the chemosensitivity in clinic. Methods: The MTT/IC50 assay was used to determine the chemosensitivity of the three breast cancer cell lines (Bcap-37, T47D, and ZR-75-30) to each of the nine anticancer drugs (paclitaxel, docetaxel, vinorelbine, 5-fluorouracil, gemcitabine, epirubicin, mitomycin, ironotecan, and cisplatin). DNA methylation profile of CpG islands in the promoter region of 23 genes of the three breast cancer cell lines was tested by methylation specific PCR. Results: The sensitivity of the three breast cancer cell lines to 5-FU showed a significant difference. Bcap-37 cells were relatively tolerant to 5-FU (IC50=317.386 μg/mL). ZR-75-30 and T47D were relatively sensitive to 5-FU (IC50=6.676 and 73.076 μg/mL, respectively). Out of the 23 genes, the methylation of 6 genes, ABCC8, CHFR, BMP3B, LOX, PRSS21, and RASSF1A, exhibited different patterns between the 5-FU-resistant and sensitive cell lines. The ABCC8, CHFR and BMP3B genes were hypermethylated in the 5-FU-resistant cell line, but LOX, PRSS21, and RASSF1A genes were hypermethylated in the 5-FU-sensitive cell line. Conclusion: There is a promising correlation of the methylation state of 6 genes with the chemosensitivity of the breast cancer cell lines to 5-FU. This study provided the evidence for further clinical evaluation and mechanism exploration." @default.
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- W1544248596 date "2009-01-25" @default.
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- W1544248596 title "ABCC8、CHFR、BMP3B、LOX、PRSS21和RASSF1A基因启动子的甲基化状态可能与3种乳腺癌细胞株对5-FU的敏感性相关" @default.
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