FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544254927> ?p ?o ?g. }

• W1544254927 endingPage "167" @default.
• W1544254927 startingPage "155" @default.
• W1544254927 abstract "Insulin-regulated aminopeptidase (IRAP) is a marker for insulin-sensitive recycling compartments of fat and muscle cells that contain the glucose transporter isoform GLUT4. Unlike GLUT4, IRAP is expressed in many other cell types. Thus, it is a potential marker for regulated recycling compartments that are analogous to GLUT4 vesicles. In bone marrow-derived mast cells, IRAP is highly expressed and localizes to an intracellular compartment different from secretory granules. Using cell-surface biotinylation, we determined that IRAP underwent rapid redistribution to the plasma membrane on antigen/immunoglobulin E (IgE) stimulation and was re-internalized within 30 min. When granule exocytosis was inhibited, by removing extracellular calcium, adding the protein kinase C inhibitor bisindolylmaleimide or the phosphatidylinositol 3-kinase inhibitor wortmannin, IRAP redistribution was still detected in stimulated cells. However, the redistribution of IRAP required intracellular calcium. By immunofluorescence, IRAP significantly co-localized with the transferrin receptor (TfR), a marker for constitutively recycling endosomes. However, antigen/IgE stimulation did not increase TfR on the cell surface, indicating that IRAP and TfR may follow different pathways to the plasma membrane. In rat peritoneal mast cells, the distributions of IRAP and TfR overlapped to only a limited extent, indicating that overlap may decrease with cell differentiation. We propose that IRAP vesicles represent a second IgE-sensitive exocytotic compartment in mast cells, which is regulated differently from secretory granules, and that these vesicles may be similar to GLUT4 vesicles." @default.
• W1544254927 created "2016-06-24" @default.
• W1544254927 creator A5039630705 @default.
• W1544254927 creator A5052794857 @default.
• W1544254927 creator A5076239980 @default.
• W1544254927 date "2006-01-09" @default.
• W1544254927 modified "2023-10-16" @default.
• W1544254927 title "Insulin-Regulated Aminopeptidase Marks an Antigen-Stimulated Recycling Compartment in Mast Cells" @default.
• W1544254927 cites W107887590 @default.
• W1544254927 cites W1530924707 @default.
• W1544254927 cites W1557874430 @default.
• W1544254927 cites W1563664354 @default.
• W1544254927 cites W1575638250 @default.
• W1544254927 cites W1594060168 @default.
• W1544254927 cites W1634886886 @default.
• W1544254927 cites W1750204594 @default.
• W1544254927 cites W185753168 @default.
• W1544254927 cites W1895068341 @default.
• W1544254927 cites W1965842427 @default.
• W1544254927 cites W1977797021 @default.
• W1544254927 cites W1979688230 @default.
• W1544254927 cites W1987613834 @default.
• W1544254927 cites W1992372943 @default.
• W1544254927 cites W1993091864 @default.
• W1544254927 cites W1995931935 @default.
• W1544254927 cites W2005439632 @default.
• W1544254927 cites W2007089466 @default.
• W1544254927 cites W2007308578 @default.
• W1544254927 cites W2014972849 @default.
• W1544254927 cites W2021069555 @default.
• W1544254927 cites W2021305554 @default.
• W1544254927 cites W2021939646 @default.
• W1544254927 cites W2024301716 @default.
• W1544254927 cites W2029578910 @default.
• W1544254927 cites W2031943544 @default.
• W1544254927 cites W2032118781 @default.
• W1544254927 cites W2044618871 @default.
• W1544254927 cites W2049609626 @default.
• W1544254927 cites W2049705063 @default.
• W1544254927 cites W2053533223 @default.
• W1544254927 cites W2062401346 @default.
• W1544254927 cites W2063897756 @default.
• W1544254927 cites W2076789660 @default.
• W1544254927 cites W2076941419 @default.
• W1544254927 cites W2077239553 @default.
• W1544254927 cites W2079129143 @default.
• W1544254927 cites W2082941540 @default.
• W1544254927 cites W2087980780 @default.
• W1544254927 cites W2091903144 @default.
• W1544254927 cites W2092294261 @default.
• W1544254927 cites W2092925080 @default.
• W1544254927 cites W2094986417 @default.
• W1544254927 cites W2096437759 @default.
• W1544254927 cites W2097416981 @default.
• W1544254927 cites W2109436148 @default.
• W1544254927 cites W2116277908 @default.
• W1544254927 cites W2120057176 @default.
• W1544254927 cites W2121486692 @default.
• W1544254927 cites W2128574573 @default.
• W1544254927 cites W2128848954 @default.
• W1544254927 cites W2129935560 @default.
• W1544254927 cites W2131440433 @default.
• W1544254927 cites W2138099953 @default.
• W1544254927 cites W2140202716 @default.
• W1544254927 cites W2143339101 @default.
• W1544254927 cites W2143487345 @default.
• W1544254927 cites W2145554557 @default.
• W1544254927 cites W2147425691 @default.
• W1544254927 cites W2150032835 @default.
• W1544254927 cites W2157815316 @default.
• W1544254927 cites W2161827401 @default.
• W1544254927 cites W2164746164 @default.
• W1544254927 cites W2265732660 @default.
• W1544254927 cites W2341867771 @default.
• W1544254927 cites W2394842998 @default.
• W1544254927 cites W2399280246 @default.
• W1544254927 cites W2410707077 @default.
• W1544254927 cites W4211044652 @default.
• W1544254927 cites W4229688459 @default.
• W1544254927 doi "https://doi.org/10.1111/j.1600-0854.2006.00373.x" @default.
• W1544254927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16420524" @default.
• W1544254927 hasPublicationYear "2006" @default.
• W1544254927 type Work @default.
• W1544254927 sameAs 1544254927 @default.
• W1544254927 citedByCount "16" @default.
• W1544254927 countsByYear W15442549272012 @default.
• W1544254927 countsByYear W15442549272014 @default.
• W1544254927 countsByYear W15442549272016 @default.
• W1544254927 countsByYear W15442549272019 @default.
• W1544254927 countsByYear W15442549272020 @default.
• W1544254927 countsByYear W15442549272022 @default.
• W1544254927 countsByYear W15442549272023 @default.
• W1544254927 crossrefType "journal-article" @default.
• W1544254927 hasAuthorship W1544254927A5039630705 @default.
• W1544254927 hasAuthorship W1544254927A5052794857 @default.
• W1544254927 hasAuthorship W1544254927A5076239980 @default.
• W1544254927 hasBestOaLocation W15442549271 @default.
• W1544254927 hasConcept C130316041 @default.

• next