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• W1544320453 abstract "Objectives To analyse the predictive factors for worse pathological outcome (muscle invasive pT2 +, non‐organ‐confined pT3 + or N + and histological G rade 3) of upper tract urothelial carcinoma ( UTUC ) in a C hinese population from a nationwide high‐volume centre in C hina. Patients and Methods Predictors were studied by retrospectively reviewing the clinicopathological data of 729 consecutive patients with UTUC treated in our centre from J anuary 2002 to D ecember 2010. Univariate and multivariate logistic regression analyses were used. Results There were more female patients (56.4%) than males and more tumours were located in the ureter (52.7%) than in the pelvis. In multivariate analysis, male gender (hazard ratio [ HR ] 1.898, P = 0.001), sessile architecture ( HR 3.249, P < 0.001), high grade ( HR 5.007, P < 0.001), ipsilateral hydronephrosis ( HR 4.768, P < 0.001), renal pelvis location ( HR 2.620, P < 0.001) and tumour without multifocality ( HR 1.639, P = 0.028) were predictive factors for muscle‐invasive UTUC . Male gender ( HR 2.132, P < 0.001), renal pelvis location ( HR 3.466, P < 0.001), tumour without multifocality ( HR 2.532, P = 0.001), sessile tumour architecture ( HR 3.274, P < 0.001), and high grade ( HR 3.019, P < 0.001) were predictive factors for non‐organ‐confined disease. Chronological old age ( HR 1.047, P < 0.001), sessile tumour architecture ( HR 25.192, P < 0.001), ipsilateral hydronephrosis ( HR 1.689, P = 0.024), and positive urinary cytology ( HR 1.997, P = 0.006) were predictive factors for histological G rade 3 UTUC . Conclusions There was a predominance of female patients and ureteric tumours in UTUCs of this C hinese population. Male gender, sessile architecture, tumour location, tumour without multifocality, high histological grade and preoperative ipsilateral hydronephrosis were independent predictive factors for worse pathological outcome of UTUCs ." @default.
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• W1544320453 date "2013-07-26" @default.
• W1544320453 modified "2023-10-15" @default.
• W1544320453 title "Predictive factors for worse pathological outcomes of upper tract urothelial carcinoma: experience from a nationwide high‐volume centre in <scp>C</scp>hina" @default.
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• W1544320453 doi "https://doi.org/10.1111/bju.12238" @default.
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