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- W1544337614 abstract "The absolute configuration of primary and secondary alcohols, primary amines, carboxylic acids, thiols, cyanohydrins, sec/sec- and prim/sec-diols, sec/sec- and prim/sec-amino alcohols, and prim/sec/sec-triols can be established very rapidly by NMR of their derivatives formed with certain chiral derivatizing agents (CDAs), such as MPA, MTPA, 9-AMA, 1-NMA, 2-NMA, BPG and 2-NTBA. In general, the method requires: 1) the preparation of two diastereomeric derivatives of the substrate by its reaction with the two enantiomers of the CDA and 2) the comparison of the NMR signals of the derivatives, especially those corresponding to the substituents (i.e. L1/L2) directly bonded to the asymmetric carbon of the substrate. In this Chapter we present simplified procedures leading to the assignment of absolute configuration with a) a significant reduction of the number of derivatives that should be prepared and b) the amount of sample needed, c) the elimination of the bench-effort involved in the preparation of the derivatives and d) the automatization of the assignment process." @default.
- W1544337614 created "2016-06-24" @default.
- W1544337614 creator A5030433820 @default.
- W1544337614 creator A5036131251 @default.
- W1544337614 creator A5051408653 @default.
- W1544337614 date "2014-12-19" @default.
- W1544337614 modified "2023-10-17" @default.
- W1544337614 title "Simplified NMR Procedures for the Assignment of the Absolute Configuration" @default.
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- W1544337614 doi "https://doi.org/10.1002/9783527664610.ch7" @default.
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