Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544346049> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1544346049 endingPage "1538" @default.
- W1544346049 startingPage "1531" @default.
- W1544346049 abstract "Abstract Objectives Spray-dried emulsion (SDE) was prepared and characterized to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac, currently under preclinical development. Methods The intestinal absorption of ZLR-8 was characterized by single pass intestinal perfusion technique to obtain its absorption and permeability parameters. SDE of ZLR-8 was prepared and characterized by particle size measurements and in-vitro release study. Accurate and precise RP-HPLC methods for the detection of ZLR-8 and its metabolite diclofenac were constructed to perform the bioavailability study. Key findings It was demonstrated that ZLR-8 was absorbed in the whole intestine, of which the duodenum segment exhibited the largest absorption ability. ZLR-8 can be classified into BCS Class 2. SDE significantly enhanced the intestinal absorption rate of ZLR-8 in duodenum and jejunum but had indistinctive effect on permeability. All concentrations of ZLR-8 in rat plasma was lower than the limit of detection. A bicompartment model gave the best fit to the plasma diclofenac concentration–time curves. Calculated on AUC0–12h, the mean relative bioavailability of SDE was 105.4-fold that of ZLR-8 suspension. Conclusions SDE significantly improved the intestinal absorption of ZLR-8 and resulted in a dramatic improvement in its bioavailability." @default.
- W1544346049 created "2016-06-24" @default.
- W1544346049 creator A5008614366 @default.
- W1544346049 creator A5025095617 @default.
- W1544346049 creator A5040814429 @default.
- W1544346049 creator A5080265152 @default.
- W1544346049 date "2011-09-27" @default.
- W1544346049 modified "2023-09-27" @default.
- W1544346049 title "Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac" @default.
- W1544346049 cites W1552183320 @default.
- W1544346049 cites W1978383324 @default.
- W1544346049 cites W1980759270 @default.
- W1544346049 cites W2000431143 @default.
- W1544346049 cites W2027215136 @default.
- W1544346049 cites W2040690076 @default.
- W1544346049 cites W2041804090 @default.
- W1544346049 cites W2061155379 @default.
- W1544346049 cites W2068212416 @default.
- W1544346049 cites W2075333700 @default.
- W1544346049 cites W2080955156 @default.
- W1544346049 cites W2089086903 @default.
- W1544346049 cites W2090955033 @default.
- W1544346049 cites W2091015790 @default.
- W1544346049 cites W2094977785 @default.
- W1544346049 cites W2168312459 @default.
- W1544346049 cites W2171791920 @default.
- W1544346049 cites W325492996 @default.
- W1544346049 doi "https://doi.org/10.1111/j.2042-7158.2011.01357.x" @default.
- W1544346049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22060283" @default.
- W1544346049 hasPublicationYear "2011" @default.
- W1544346049 type Work @default.
- W1544346049 sameAs 1544346049 @default.
- W1544346049 citedByCount "6" @default.
- W1544346049 countsByYear W15443460492012 @default.
- W1544346049 countsByYear W15443460492016 @default.
- W1544346049 countsByYear W15443460492018 @default.
- W1544346049 crossrefType "journal-article" @default.
- W1544346049 hasAuthorship W1544346049A5008614366 @default.
- W1544346049 hasAuthorship W1544346049A5025095617 @default.
- W1544346049 hasAuthorship W1544346049A5040814429 @default.
- W1544346049 hasAuthorship W1544346049A5080265152 @default.
- W1544346049 hasConcept C112705442 @default.
- W1544346049 hasConcept C125287762 @default.
- W1544346049 hasConcept C159985019 @default.
- W1544346049 hasConcept C181389837 @default.
- W1544346049 hasConcept C185592680 @default.
- W1544346049 hasConcept C192562407 @default.
- W1544346049 hasConcept C2776809568 @default.
- W1544346049 hasConcept C2777226302 @default.
- W1544346049 hasConcept C2778123984 @default.
- W1544346049 hasConcept C2779826273 @default.
- W1544346049 hasConcept C2781071285 @default.
- W1544346049 hasConcept C43617362 @default.
- W1544346049 hasConcept C55493867 @default.
- W1544346049 hasConcept C71924100 @default.
- W1544346049 hasConcept C90924648 @default.
- W1544346049 hasConcept C98274493 @default.
- W1544346049 hasConceptScore W1544346049C112705442 @default.
- W1544346049 hasConceptScore W1544346049C125287762 @default.
- W1544346049 hasConceptScore W1544346049C159985019 @default.
- W1544346049 hasConceptScore W1544346049C181389837 @default.
- W1544346049 hasConceptScore W1544346049C185592680 @default.
- W1544346049 hasConceptScore W1544346049C192562407 @default.
- W1544346049 hasConceptScore W1544346049C2776809568 @default.
- W1544346049 hasConceptScore W1544346049C2777226302 @default.
- W1544346049 hasConceptScore W1544346049C2778123984 @default.
- W1544346049 hasConceptScore W1544346049C2779826273 @default.
- W1544346049 hasConceptScore W1544346049C2781071285 @default.
- W1544346049 hasConceptScore W1544346049C43617362 @default.
- W1544346049 hasConceptScore W1544346049C55493867 @default.
- W1544346049 hasConceptScore W1544346049C71924100 @default.
- W1544346049 hasConceptScore W1544346049C90924648 @default.
- W1544346049 hasConceptScore W1544346049C98274493 @default.
- W1544346049 hasIssue "12" @default.
- W1544346049 hasLocation W15443460491 @default.
- W1544346049 hasLocation W15443460492 @default.
- W1544346049 hasOpenAccess W1544346049 @default.
- W1544346049 hasPrimaryLocation W15443460491 @default.
- W1544346049 hasRelatedWork W2042287403 @default.
- W1544346049 hasRelatedWork W2042840311 @default.
- W1544346049 hasRelatedWork W2076497495 @default.
- W1544346049 hasRelatedWork W2080955156 @default.
- W1544346049 hasRelatedWork W2083067870 @default.
- W1544346049 hasRelatedWork W2400119402 @default.
- W1544346049 hasRelatedWork W2425576493 @default.
- W1544346049 hasRelatedWork W2606334551 @default.
- W1544346049 hasRelatedWork W2740387668 @default.
- W1544346049 hasRelatedWork W2897419654 @default.
- W1544346049 hasVolume "63" @default.
- W1544346049 isParatext "false" @default.
- W1544346049 isRetracted "false" @default.
- W1544346049 magId "1544346049" @default.
- W1544346049 workType "article" @default.