Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544360799> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1544360799 endingPage "132.13" @default.
- W1544360799 startingPage "132.13" @default.
- W1544360799 abstract "Abstract Tuberculosis (TB) continues to pose a significant health risk to morbidity and mortality worldwide. The vast majority of individuals infected with M. tuberculosis, the causative agent of TB, contain the infection as clinically asymptomatic latent TB. A small minority of people do not and either present with primary active disease or reactivate over their lifetime. By examining early events in infection at the local lesion level, we aim to uncover some of the basis for the observed spectrum of TB disease and host outcome. Using genetically barcoded M. tuberculosis, serial PET/CT lesion imaging, and tools to analyze each granuloma at the microbial and immunological level, we are tracking local lesion development and dissemination at various stages of infection in cynomolgus macaques. Background studies have revealed that granulomas are dynamic entities that largely arise from single bacteria. We hypothesize that early interactions between M. tuberculosis and host immune components contribute to lesion heterogeneity and that these initial events influence infection outcome. We performed a small reinfection experiment with M. tuberculosis barcoded strains. Our data suggests that primary infection limits secondary infection lesion development and dissemination. Further analysis of this study is ongoing. Probing the mechanisms that underlie the human TB spectrum will reveal crucial stages of infection that can be exploited for novel therapeutic design." @default.
- W1544360799 created "2016-06-24" @default.
- W1544360799 creator A5065250926 @default.
- W1544360799 creator A5078241841 @default.
- W1544360799 creator A5080075194 @default.
- W1544360799 creator A5087831220 @default.
- W1544360799 date "2014-05-01" @default.
- W1544360799 modified "2023-09-26" @default.
- W1544360799 title "Early in vivo infection dynamics in non-human primates infected with <i>Mycobacterium tuberculosis</i> (MPF3P.813)" @default.
- W1544360799 doi "https://doi.org/10.4049/jimmunol.192.supp.132.13" @default.
- W1544360799 hasPublicationYear "2014" @default.
- W1544360799 type Work @default.
- W1544360799 sameAs 1544360799 @default.
- W1544360799 citedByCount "0" @default.
- W1544360799 crossrefType "journal-article" @default.
- W1544360799 hasAuthorship W1544360799A5065250926 @default.
- W1544360799 hasAuthorship W1544360799A5078241841 @default.
- W1544360799 hasAuthorship W1544360799A5080075194 @default.
- W1544360799 hasAuthorship W1544360799A5087831220 @default.
- W1544360799 hasConcept C142724271 @default.
- W1544360799 hasConcept C203014093 @default.
- W1544360799 hasConcept C2777910003 @default.
- W1544360799 hasConcept C2777975735 @default.
- W1544360799 hasConcept C2779134260 @default.
- W1544360799 hasConcept C2780140890 @default.
- W1544360799 hasConcept C2781069245 @default.
- W1544360799 hasConcept C2781156865 @default.
- W1544360799 hasConcept C71924100 @default.
- W1544360799 hasConcept C86803240 @default.
- W1544360799 hasConcept C8891405 @default.
- W1544360799 hasConceptScore W1544360799C142724271 @default.
- W1544360799 hasConceptScore W1544360799C203014093 @default.
- W1544360799 hasConceptScore W1544360799C2777910003 @default.
- W1544360799 hasConceptScore W1544360799C2777975735 @default.
- W1544360799 hasConceptScore W1544360799C2779134260 @default.
- W1544360799 hasConceptScore W1544360799C2780140890 @default.
- W1544360799 hasConceptScore W1544360799C2781069245 @default.
- W1544360799 hasConceptScore W1544360799C2781156865 @default.
- W1544360799 hasConceptScore W1544360799C71924100 @default.
- W1544360799 hasConceptScore W1544360799C86803240 @default.
- W1544360799 hasConceptScore W1544360799C8891405 @default.
- W1544360799 hasIssue "1_Supplement" @default.
- W1544360799 hasLocation W15443607991 @default.
- W1544360799 hasOpenAccess W1544360799 @default.
- W1544360799 hasPrimaryLocation W15443607991 @default.
- W1544360799 hasRelatedWork W1544360799 @default.
- W1544360799 hasRelatedWork W2033878713 @default.
- W1544360799 hasRelatedWork W2118527316 @default.
- W1544360799 hasRelatedWork W2168051914 @default.
- W1544360799 hasRelatedWork W2171627501 @default.
- W1544360799 hasRelatedWork W2187579610 @default.
- W1544360799 hasRelatedWork W2322029862 @default.
- W1544360799 hasRelatedWork W2903273826 @default.
- W1544360799 hasRelatedWork W3032124789 @default.
- W1544360799 hasRelatedWork W4306839112 @default.
- W1544360799 hasVolume "192" @default.
- W1544360799 isParatext "false" @default.
- W1544360799 isRetracted "false" @default.
- W1544360799 magId "1544360799" @default.
- W1544360799 workType "article" @default.