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- W1544379495 abstract "Acquired subepidermal bullous diseases are a heterogeneous group of acquired blistering diseases. They may affect patients' skin (bullous pemphigoid (BP)) and mucous membranes (mucous membrane pemphigoid (MMP)) to different extents and can lead to scar formation. Few randomized controlled trials are available; the evidence is inadequate to allow confident recommendation of optimal treatment. Systemic steroids are the best established treatment for BP. Immunosuppressive and metabolic adverse effects occur and are dose dependent. Very potent topical steroids are an effective treatment. Anti-inflammatory effects of antimicrobials and nicotinamide may be effective. In mild ocular MMP, dapsone combined with systemic corticosteroids may be helpful. Cyclophosphamide combined with systemic corticosteroids, with or without pentoxifylline, appears to suppress inflammation and scarring in moderate to severe disease. The benefits of azathioprine, mycophenolate mofetil, plasma exchange, intravenous immunoglobulins, and biologics in both BP and MMP are difficult to assess." @default.
- W1544379495 created "2016-06-24" @default.
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- W1544379495 date "2014-06-06" @default.
- W1544379495 modified "2023-10-17" @default.
- W1544379495 title "Acquired Subepidermal Bullous Diseases" @default.
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- W1544379495 doi "https://doi.org/10.1002/9781118357606.ch64" @default.
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