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- W1544382002 abstract "Interleukin-17 (IL-17), the signature cytokine produced by T helper 17 (Th17) cells, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17 promotes the expression of cytokines and proteins involved in inflammatory responses, via the induction of gene transcription and post-transcription stabilization of mRNA. These functions are mediated by CIKS, an adaptor protein that is recruited to the receptor after IL-17 stimulation.We shows here that LRRFIP1 isoform 3 is a new CIKS interactor. Overexpression of LRRFIP1 isoform 3 blocks the IL-17 induced gene expression, via down-regulation of NF-κB and AP-1. Accordingly, down-regulation of LRRFIP1 enhanced the expression of cxcl1 and il-6 after IL-17 stimulation.LRRFIP 1 isoform 3 exerts this function by interfering with the recruitment of CIKS to the cytoplasmic domain of the IL-17 receptor.Collectively our finding defines a new mechanism regulating the inflammatory response." @default.
- W1544382002 created "2016-06-24" @default.
- W1544382002 creator A5012380844 @default.
- W1544382002 date "2014-03-31" @default.
- W1544382002 modified "2023-09-23" @default.
- W1544382002 title "LRRFIP1 negatively regulates IL-17 signalling by binding toCIKS" @default.
- W1544382002 hasPublicationYear "2014" @default.
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