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• W1544487163 abstract "Experimental two‐dimensional 1 H NMR data have been obtained for PrP106–128 under the following solvent conditions: deionized water/2,2,2‐trifluoroethanol 50 : 50 (v/v) and dimethylsulfoxide. These data were analyzed by restrained molecular mechanics calculations to determine how changes in solvation affect the conformation of the peptide. In deionized water at pH 3.5, the peptide adopted a helical conformation in the hydrophobic region spanning residues Met112–Leu125, with the most populated helical region corresponding to the Ala115–Ala119 segment (≈ 10%). In trifluoroethanol/H 2 O, the α‐helix increased in population especially in the Gly119–Val122 tract (≈ 25%). The conformation of this region was found to be remarkably sensitive to pH, as the Ala120–Gly124 tract shifted to an extended conformation at pH 7. In dimethylsulfoxide, the hydrophobic cluster adopted a prevalently extended conformation. For all tested solvents the region spanning residues Asn108–Met112 was present in a ‘turn‐like’ conformation and included His111, situated just before the starting point of the α‐helix. Rather than by conformational changes, the effect of His111 is exerted by changes in its hydrophobicity, triggering aggregation. The amphiphilic properties and the pH‐dependent ionizable side‐chain of His111 may thus be important for the modulation of the conformational mobility and heterogeneity of PrP106–126." @default.
• W1544487163 created "2016-06-24" @default.
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• W1544487163 date "1999-12-15" @default.
• W1544487163 modified "2023-10-17" @default.
• W1544487163 title "Determination of solution conformations of PrP106-126, a neurotoxic fragment of prion protein, by¹H NMR and restrained molecular dynamics" @default.
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• W1544487163 doi "https://doi.org/10.1046/j.1432-1327.1999.00985.x" @default.
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