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• W1544492955 endingPage "18734" @default.
• W1544492955 startingPage "18728" @default.
• W1544492955 abstract "Rat L6E9 muscle cells commit to terminal differentiation by forming a large muscle syncitia complete with the expression of a large number of muscle-specific contractile protein genes. To determine whether these cells, which fail to synthesize MLC (myosin light chain) 1 and cardiac alpha-actin, exhibit a deficiency in the expression of muscle determination genes, we measured expression of MyoD1, myogenin, Myf-5, and MRF-4. Results show these cells do not synthesize MyoD1, yet express the other myogenic determination genes. Transient expression of exogenous MyoD1 in these cells is sufficient to activate endogenous MLC 1 and cardiac alpha-actin mRNA synthesis during muscle differentiation. Previously undetected myosin heavy chain (MHC) isoforms (beta-MHC and perinatal MHC) are also transcribed at low levels in L6E9 muscle cells, and in MyoD1-transfected L6E9 cells no change occurs in their expression. Furthermore, treatment with the demethylating agent 5-azacytidine activates expression of the endogenous MyoD1 gene in L6E9 cells and, subsequently, rescues deficiencies in their myogenic biochemical program. These results demonstrate that the endogenous MyoD1 gene in L6E9 cells is not defective and can be functionally activated. Also, the MyoD1 protein plays an essential role, which cannot be compensated by other known muscle determination proteins, in the induction of MLC 1 and cardiac alpha-actin expression." @default.
• W1544492955 created "2016-06-24" @default.
• W1544492955 creator A5018498698 @default.
• W1544492955 creator A5073632726 @default.
• W1544492955 creator A5077699343 @default.
• W1544492955 date "1992-09-01" @default.
• W1544492955 modified "2023-09-29" @default.
• W1544492955 title "Induction of endogenous myosin light chain 1 and cardiac alpha-actin expression in L6E9 cells by MyoD1." @default.
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• W1544492955 doi "https://doi.org/10.1016/s0021-9258(19)37022-x" @default.
• W1544492955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1382061" @default.
• W1544492955 hasPublicationYear "1992" @default.
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