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- W1544502080 abstract "A novel molecular modelling study is described which involves the construction of a substrate-haem complex (as a representation of the active site) for a P450 based enzyme involving the positioning of the haem about the steroid C(20). The complex was then utilized to study the binding (to the P450 haem) of the steroidal and nonsteroidal reversible inhibitors of the 17,20-lyase component of the enzyme complex 17α-hydroxylase/17,20-lyase to gain insight into its active site.The results of the study appear to agree with a recent report on the binding of the reversible steroidal inhibitor 17-(3-pyridyl) androsta-5,16-dien-3β-ol. Using the substrate-haem complex, we consider the probable reasons for the observed inhibitory activity within the four enantiomers of ketoconazole and other similar antimycotic compounds, such as miconazole." @default.
- W1544502080 created "2016-06-24" @default.
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- W1544502080 date "1996-05-01" @default.
- W1544502080 modified "2023-09-26" @default.
- W1544502080 title "A Novel Molecular-modelling Study of some Inhibitors of 17,20-Lyase. The Substrate-Haem Complex Approach" @default.
- W1544502080 doi "https://doi.org/10.1111/j.2042-7158.1996.tb00604.x" @default.
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