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- W1544564404 abstract "Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human cells microinjected with anti-cyclin A antibodies at distinct times. Cyclin A binds both cdk2 and cdc2, giving two distinct cyclin A kinase activities, one appearing in S phase, the other in G2. These results suggest that cyclin A defines novel control points of the human cell cycle." @default.
- W1544564404 created "2016-06-24" @default.
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- W1544564404 creator A5059014336 @default.
- W1544564404 date "1992-03-01" @default.
- W1544564404 modified "2023-10-10" @default.
- W1544564404 title "Cyclin A is required at two points in the human cell cycle." @default.
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- W1544564404 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05135.x" @default.
- W1544564404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556537" @default.
- W1544564404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1312467" @default.
- W1544564404 hasPublicationYear "1992" @default.
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