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• W1544608701 abstract "Polar packaging of adenovirus DNA into virions is dependent on the presence of cis-acting sequences at the left end of the viral genome. Our previous analyses demonstrated that the adenovirus type 5 (Ad5) packaging domain (nucleotides 194 to 358) is composed of at least five elements that are functionally redundant. A repeated sequence, termed the A repeat, was associated with packaging function. Here we report a more detailed analysis of the requirements for the selective packaging of Ad5 DNA. By introducing site-directed point mutations into specific A repeat sequences, we demonstrate that the A repeats represent cis-acting functional components of the packaging signal. Additional elements, located outside the originally defined packaging domain boundaries and that resemble the A repeat consensus sequence, also are capable of promoting the packaging of viral DNA. The cis-acting components of the packaging signal appear to be subject to certain spatial constraints for function, possibly reflecting a necessity for the coordinate binding of packaging proteins to these sites. In agreement with this idea, we present evidence that the interaction of a limiting trans-acting factor(s) with the packaging domain in vivo is required for efficient encapsidation of the Ad5 genome." @default.
• W1544608701 created "2016-06-24" @default.
• W1544608701 creator A5056559586 @default.
• W1544608701 creator A5063322136 @default.
• W1544608701 date "1992-02-01" @default.
• W1544608701 modified "2023-10-14" @default.
• W1544608701 title "cis and trans requirements for the selective packaging of adenovirus type 5 DNA" @default.
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• W1544608701 doi "https://doi.org/10.1128/jvi.66.2.723-731.1992" @default.
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