FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544652523> ?p ?o ?g. }

• W1544652523 endingPage "7477" @default.
• W1544652523 startingPage "7470" @default.
• W1544652523 abstract "The effects of the expression of the protein tyrosine kinase pp60v-src on endothelin- and thrombin-stimulated inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) production and calcium responses were investigated in Rat-1 fibroblasts. The ability of endothelin-1 to induce the accumulation of these second messengers was dramatically amplified by v-src transformation, with 6- and 3-fold enhancements of the peak Ins(1,4,5)P3 and peak calcium responses, respectively. In contrast, thrombin-dependent responses were slightly reduced following v-src transformation, demonstrating that the augmentation of endothelin-stimulated signal transduction is a selective effect. The magnitude of the stimulated accumulation of Ins(1,4,5)P3 presumably depends upon both the functional activation of phospholipase C to produce Ins(1,4,5)P3, and the activity of the enzymes that metabolize Ins(1,4,5)P3. Although the metabolism of Ins(1,4,5)P3 was strikingly altered by expression of pp60v-src, with a bias towards the production of higher inositol polyphosphates that is consistent with an activated Ins(1,4,5)P3 3-kinase, this change could not account for the marked increase in endothelin-stimulated signaling induced by v-src transformation. This suggests that an effect of pp60v-src is expressed at the level of the plasma membrane, through an interaction with one or more components in the receptor/guanine nucleotide binding protein (G protein)/phospholipase C system that transduces the endothelin signal into Ins(1,4,5)P3 production. Preparation of membranes from normal and v-src-transformed cells showed that, while there was no change in the number of high-affinity endothelin binding sites, the release of Ins(1,4,5)P3 in response to guanine nucleotides and endothelin-1 was significantly increased following v-src transformation. In contrast, the Ins(1,4,5)P3 responses to thrombin and high Ca2+ concentrations were unaffected by transformation. Thus the selective interactions within the G protein system that couples the endothelin receptor to phospholipase C are potential sites at which the v-src transformation process may act to amplify endothelin-dependent Ins(1,4,5)P3 production." @default.
• W1544652523 created "2016-06-24" @default.
• W1544652523 creator A5012201632 @default.
• W1544652523 creator A5014881358 @default.
• W1544652523 creator A5065802163 @default.
• W1544652523 creator A5071945560 @default.
• W1544652523 date "1992-04-01" @default.
• W1544652523 modified "2023-09-28" @default.
• W1544652523 title "Selective amplification of endothelin-stimulated inositol 1,4,5-trisphosphate and calcium signaling by v-src transformation of rat-1 fibroblasts." @default.
• W1544652523 cites W1038394818 @default.
• W1544652523 cites W110752903 @default.
• W1544652523 cites W1534013912 @default.
• W1544652523 cites W1551650181 @default.
• W1544652523 cites W1562922570 @default.
• W1544652523 cites W1775749144 @default.
• W1544652523 cites W1938975553 @default.
• W1544652523 cites W1969006090 @default.
• W1544652523 cites W1971333358 @default.
• W1544652523 cites W1972760976 @default.
• W1544652523 cites W1986713457 @default.
• W1544652523 cites W2005963663 @default.
• W1544652523 cites W2009377621 @default.
• W1544652523 cites W2018885253 @default.
• W1544652523 cites W2034185792 @default.
• W1544652523 cites W2049761007 @default.
• W1544652523 cites W2050356686 @default.
• W1544652523 cites W2062748780 @default.
• W1544652523 cites W2068877244 @default.
• W1544652523 cites W2075948115 @default.
• W1544652523 cites W2085968319 @default.
• W1544652523 cites W2094586019 @default.
• W1544652523 cites W2094645760 @default.
• W1544652523 cites W2124559327 @default.
• W1544652523 cites W2141260882 @default.
• W1544652523 cites W2149439788 @default.
• W1544652523 cites W2156872475 @default.
• W1544652523 cites W2230663629 @default.
• W1544652523 cites W2260076009 @default.
• W1544652523 cites W2286120744 @default.
• W1544652523 cites W230487446 @default.
• W1544652523 cites W2341906350 @default.
• W1544652523 cites W2411202029 @default.
• W1544652523 doi "https://doi.org/10.1016/s0021-9258(18)42541-0" @default.
• W1544652523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1559985" @default.
• W1544652523 hasPublicationYear "1992" @default.
• W1544652523 type Work @default.
• W1544652523 sameAs 1544652523 @default.
• W1544652523 citedByCount "29" @default.
• W1544652523 countsByYear W15446525232012 @default.
• W1544652523 countsByYear W15446525232017 @default.
• W1544652523 crossrefType "journal-article" @default.
• W1544652523 hasAuthorship W1544652523A5012201632 @default.
• W1544652523 hasAuthorship W1544652523A5014881358 @default.
• W1544652523 hasAuthorship W1544652523A5065802163 @default.
• W1544652523 hasAuthorship W1544652523A5071945560 @default.
• W1544652523 hasBestOaLocation W15446525231 @default.
• W1544652523 hasConcept C104317684 @default.
• W1544652523 hasConcept C108636557 @default.
• W1544652523 hasConcept C144980905 @default.
• W1544652523 hasConcept C153911025 @default.
• W1544652523 hasConcept C170493617 @default.
• W1544652523 hasConcept C178790620 @default.
• W1544652523 hasConcept C185592680 @default.
• W1544652523 hasConcept C204241405 @default.
• W1544652523 hasConcept C2777427919 @default.
• W1544652523 hasConcept C2778618036 @default.
• W1544652523 hasConcept C519063684 @default.
• W1544652523 hasConcept C55493867 @default.
• W1544652523 hasConcept C62478195 @default.
• W1544652523 hasConcept C66135807 @default.
• W1544652523 hasConcept C80631254 @default.
• W1544652523 hasConcept C86803240 @default.
• W1544652523 hasConcept C95444343 @default.
• W1544652523 hasConceptScore W1544652523C104317684 @default.
• W1544652523 hasConceptScore W1544652523C108636557 @default.
• W1544652523 hasConceptScore W1544652523C144980905 @default.
• W1544652523 hasConceptScore W1544652523C153911025 @default.
• W1544652523 hasConceptScore W1544652523C170493617 @default.
• W1544652523 hasConceptScore W1544652523C178790620 @default.
• W1544652523 hasConceptScore W1544652523C185592680 @default.
• W1544652523 hasConceptScore W1544652523C204241405 @default.
• W1544652523 hasConceptScore W1544652523C2777427919 @default.
• W1544652523 hasConceptScore W1544652523C2778618036 @default.
• W1544652523 hasConceptScore W1544652523C519063684 @default.
• W1544652523 hasConceptScore W1544652523C55493867 @default.
• W1544652523 hasConceptScore W1544652523C62478195 @default.
• W1544652523 hasConceptScore W1544652523C66135807 @default.
• W1544652523 hasConceptScore W1544652523C80631254 @default.
• W1544652523 hasConceptScore W1544652523C86803240 @default.
• W1544652523 hasConceptScore W1544652523C95444343 @default.
• W1544652523 hasIssue "11" @default.
• W1544652523 hasLocation W15446525231 @default.
• W1544652523 hasOpenAccess W1544652523 @default.
• W1544652523 hasPrimaryLocation W15446525231 @default.
• W1544652523 hasRelatedWork W1544652523 @default.
• W1544652523 hasRelatedWork W1971985588 @default.
• W1544652523 hasRelatedWork W1997707596 @default.
• W1544652523 hasRelatedWork W2009586139 @default.

• next