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• W1544720912 abstract "We read with great interest the recent two studies by Hardak et al. and Enomoto et al. about the diagnosis of Pneumocystis jiroveci pneumonia (PJP) in non-human immunodeficiency virus (HIV)-infected patients.1, 2 Here, we would like to describe a case of PJP and highlight several important issues regarding the diagnosis of this disease in non-HIV-infected patients. A 32-year-old lady, who underwent allogeneic peripheral blood stem cell transplantation for leukaemia 6 months earlier, was admitted to the hospital for high fever, dry cough and progressive dyspnoea for 5 days. Chest radiography showed alveolar opacities in the bilateral lower lungs (Fig. 1a), while thin-section chest computed tomography showed major findings of subpleural consolidation, with peripheral distribution and focal ground glass opacities (GGO) in the bilateral lower lungs (Fig. 1b,c). The results of the microbiology study were inconclusive. To achieve a definitive diagnosis, surgical lung biopsies by thoracoscopy were obtained. Thoracoscopic biopsy of the right middle and lower lungs showed PJP. After a 2-week treatment, there was evolutional change from consolidation to GGO with crazy-paving pattern (Fig. 1d). The lower lung opacities resolved after 4 weeks of sulfamethoxazole-trimethoprim treatment, and she was discharged. (a) Chest radiograph showing alveolar opacities in the bilateral lower lungs and a right-sided port-a catheter; (b and c) computed tomography (CT) imaging revealed subpleural consolidation and focal ground glass opacities (GGO) with a peripheral distribution; (d) compared with the initial chest CT, there was note of evolutionary change from consolidation to GGO with crazy-paving pattern after 2 weeks of treatment. The clinical course of PJP in non-HIV-infected patients is substantially different from those of HIV-infected patients.2, 3 The disease usually presents with a more acute and fulminant course in non-HIV-infected patients.3 In contrast, the presentation is usually indolent in HIV-infected patients. In addition, the mortality rate is higher among non-HIV-infected patients.2, 3 Table 1 summarizes the differences of PJP between HIV-infected and non-HIV-infected patients. Typical computed tomography findings of PJP include diffuse GGO in a mosaic pattern, distributed mostly at the central and upper lungs, with peripheral sparing.4 However, atypical imaging presentation, such as dense consolidation and atypical distribution of the involved lungs, is not unusual in non-HIV-infected patients.3 The greater consolidation and less GGO in chest computed tomography of non-HIV-infected patients may reflect more extensive lung inflammation due to more inflammatory cells and fewer Pneumocystis organisms.5 Therefore, a consolidation-predominant pattern should not preclude a suspicion of PJP. Early diagnosis of PJP usually relies on a high index of suspicion. In non-HIV-infected patients, transplantation and corticosteroid use are two important risk factors. A susceptible host with risk factors presenting with atypical pneumonia should elicit a suspicion of this disease regardless of typical chest imaging presented. Furthermore, the imaging pattern of PJP varies with HIV-infected status and disease stage.3 Evolutionary changes may occur after treatment. In this presented case, the subpleural lesions changed from consolidation to GGO with crazy-paving pattern after 2 weeks of treatment (Fig. 1d). Nevertheless, initial GGO lesions may progress to alveolar consolidation in few days, if no definite treatment is provided. In conclusion, PJP in non-HIV-infected patients has different clinical and radiographical presentations from that in HIV-infected patients. The clinical and radiographical features from HIV-infected patients cannot be totally applied to diagnose PJP in non-HIV-infected patients." @default.
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• W1544720912 date "2012-12-26" @default.
• W1544720912 modified "2023-10-14" @default.
• W1544720912 title "Non-human immunodeficiency virusPneumocystis jirovecipneumonia" @default.
• W1544720912 cites W1934505439 @default.
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• W1544720912 doi "https://doi.org/10.1111/resp.12004" @default.
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