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- W1544771640 abstract "Abstract Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the use of DBS in schizophrenia at this point." @default.
- W1544771640 created "2016-06-24" @default.
- W1544771640 creator A5016176374 @default.
- W1544771640 creator A5023695985 @default.
- W1544771640 creator A5033022382 @default.
- W1544771640 creator A5035640797 @default.
- W1544771640 creator A5056682810 @default.
- W1544771640 creator A5062676906 @default.
- W1544771640 creator A5062981284 @default.
- W1544771640 creator A5086535320 @default.
- W1544771640 date "2014-09-01" @default.
- W1544771640 modified "2023-10-16" @default.
- W1544771640 title "Deep Brain Stimulation in Schizophrenia" @default.
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