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• W1544781036 abstract "Abstract G-CSF, its receptor, and IL-17 receptor A (IL-17RA) are all required to maintain baseline neutrophil counts in mice. In this study, we tested whether IL-17F could compensate and maintain baseline neutrophil counts in the absence of IL-17A. Unlike the reduced neutrophil counts found in IL-17RA-deficient mice, neutrophil counts were mildly increased in IL-17A-deficient (Il17a−/−) animals. There was no evidence for infection or altered neutrophil function. Plasma G-CSF and IL-17F levels were elevated in Il17a−/− compared with wild-type mice. IL-17F was mainly produced in the spleen and mesenteric lymph nodes, but IL-23 was unaltered in Il17a−/− mice. Instead, Il17a−/− splenocytes differentiated with IL-6, TGF-β, and IL-23 ex vivo produced significantly more IL-17F in response to IL-23 than wild-type cells. Adding rIL-17A to Il17a−/− splenocyte cultures reduced IL-17F mRNA and protein secretion. These effects were also observed in wild-type but not IL-17RA-deficient cells. We conclude that IL-17A mediated suppression of IL-17F production and secretion requires IL-17RA and is relevant to maintain the normal set point of blood neutrophil counts in vivo." @default.
• W1544781036 created "2016-06-24" @default.
• W1544781036 creator A5008276681 @default.
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• W1544781036 date "2009-07-15" @default.
• W1544781036 modified "2023-10-01" @default.
• W1544781036 title "IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice" @default.
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• W1544781036 doi "https://doi.org/10.4049/jimmunol.0804080" @default.
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