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- W1544786823 abstract "Eradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection upon interruption of the treatment. Therapeutic targeting of viral latency will require a better understanding of the basic mechanisms underlying the establishment and long-term maintenance of HIV-1 in resting memory CD4 T cells, the most prominent reservoir of transcriptionally silent provirus. Since the molecular mechanisms that permit long term transcriptional control of proviral gene expression in these cells are still obscure, this review aims at summarizing the various aspects of the problem that need to be considered. In particular, this review will focus the attention on the control of transcription imposed by chromatin through various epigenetic mechanisms. Exploring the molecular details of viral latency will provide new insights for eventual future therapeutics that aim at viral eradication." @default.
- W1544786823 created "2016-06-24" @default.
- W1544786823 creator A5056221917 @default.
- W1544786823 date "2006-01-16" @default.
- W1544786823 modified "2023-09-27" @default.
- W1544786823 title "Latency: the hidden HIV-1 challenge" @default.
- W1544786823 cites W144423133 @default.
- W1544786823 cites W1486954937 @default.
- W1544786823 cites W1491954563 @default.
- W1544786823 cites W1497870368 @default.
- W1544786823 cites W1522102057 @default.
- W1544786823 cites W1546915777 @default.
- W1544786823 cites W1581164772 @default.
- W1544786823 cites W1584733010 @default.
- W1544786823 cites W1593416572 @default.
- W1544786823 cites W1647075334 @default.
- W1544786823 cites W1722568879 @default.
- W1544786823 cites W1789346125 @default.
- W1544786823 cites W1916491745 @default.
- W1544786823 cites W1964660012 @default.
- W1544786823 cites W1973398091 @default.
- W1544786823 cites W1977339483 @default.
- W1544786823 cites W1983489347 @default.
- W1544786823 cites W1988195130 @default.
- W1544786823 cites W1994203761 @default.
- W1544786823 cites W1996604523 @default.
- W1544786823 cites W2000287507 @default.
- W1544786823 cites W2000337153 @default.
- W1544786823 cites W2006765654 @default.
- W1544786823 cites W2007496937 @default.
- W1544786823 cites W2007989611 @default.
- W1544786823 cites W2010081774 @default.
- W1544786823 cites W2011626958 @default.
- W1544786823 cites W2011630381 @default.
- W1544786823 cites W2018359511 @default.
- W1544786823 cites W2019508559 @default.
- W1544786823 cites W2021551755 @default.
- W1544786823 cites W2021778959 @default.
- W1544786823 cites W2022043882 @default.
- W1544786823 cites W2022098233 @default.
- W1544786823 cites W2031983597 @default.
- W1544786823 cites W2032323486 @default.
- W1544786823 cites W2033464993 @default.
- W1544786823 cites W2035404191 @default.
- W1544786823 cites W2037541952 @default.
- W1544786823 cites W2038070445 @default.
- W1544786823 cites W2040059091 @default.
- W1544786823 cites W2040544622 @default.
- W1544786823 cites W2046703358 @default.
- W1544786823 cites W2046854154 @default.
- W1544786823 cites W2052762012 @default.
- W1544786823 cites W2053584325 @default.
- W1544786823 cites W2058306877 @default.
- W1544786823 cites W2058598541 @default.
- W1544786823 cites W2060829964 @default.
- W1544786823 cites W2063628696 @default.
- W1544786823 cites W2064050331 @default.
- W1544786823 cites W2064640692 @default.
- W1544786823 cites W2072528655 @default.
- W1544786823 cites W2077488744 @default.
- W1544786823 cites W2078673393 @default.
- W1544786823 cites W2081494228 @default.
- W1544786823 cites W2082314789 @default.
- W1544786823 cites W2084851425 @default.
- W1544786823 cites W2086584161 @default.
- W1544786823 cites W2087809591 @default.
- W1544786823 cites W2088493593 @default.
- W1544786823 cites W2090040582 @default.
- W1544786823 cites W2090238266 @default.
- W1544786823 cites W2090646713 @default.
- W1544786823 cites W2090699693 @default.
- W1544786823 cites W2091070751 @default.
- W1544786823 cites W2096894782 @default.
- W1544786823 cites W2101516953 @default.
- W1544786823 cites W2106051882 @default.
- W1544786823 cites W2114654929 @default.
- W1544786823 cites W2117785982 @default.
- W1544786823 cites W2118090371 @default.
- W1544786823 cites W2119043372 @default.
- W1544786823 cites W2120704505 @default.
- W1544786823 cites W2125638681 @default.
- W1544786823 cites W2130635171 @default.
- W1544786823 cites W2130651313 @default.
- W1544786823 cites W2131466396 @default.
- W1544786823 cites W2135540929 @default.
- W1544786823 cites W2137257434 @default.
- W1544786823 cites W2137728388 @default.
- W1544786823 cites W2139250164 @default.
- W1544786823 cites W2139809565 @default.
- W1544786823 cites W2140091023 @default.
- W1544786823 cites W2142428986 @default.
- W1544786823 cites W2143511603 @default.
- W1544786823 cites W2145513589 @default.
- W1544786823 cites W2151375318 @default.
- W1544786823 cites W2153178346 @default.
- W1544786823 cites W2161553904 @default.
- W1544786823 cites W2163237181 @default.
- W1544786823 cites W2163570329 @default.
- W1544786823 cites W2163921097 @default.
- W1544786823 cites W2171228793 @default.