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- W1544892465 abstract "This chapter discusses the regulation of gene expression, which may suggest some new mechanisms of actions for (–)-deprenyl in neurodegenerative disorders. It shows that (–)-deprenyl stimulates aromatic amino acid decarboxylase (AADC) gene expression in PC12 cells, suggesting that (–)-deprenyl could exert its anti-parkinsonian effects and potentiation of L-Dopa therapy by producing more dopamine (DA), a mechanism additional to straightforward monoamine oxidase (MAO) B inhibition, thus, increasing DA levels. Because MAO B activity has not been detected in PC12 cells, this stimulation suggests the presence of a novel site of action for (–)-deprenyl. The chapter reviews a study demonstrating that (–)-deprenyl (0.1-10 μM) and other irreversible MAO B inhibitors stimulate AADC gene expression in PC12 cells. The specificity of this effect was examined by comparing (–)-deprenyl with other MAOIs. PC12 cells were treated with 10 μM of each of the following drugs for 72 h: (–)-deprenyl, MDL 72,974A [(E)-2-(4-fluorophenethyl)- 3-fluoroallylamine, an irreversible MAO B inhibitor], and pargyline (a less selective irreversible MAO B inhibitor). They all produced a dose- and time-related stimulation of AADC gene expression, whilst clorgyline (a selective irreversible MAO A inhibitor) and Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide, a reversible MAO B inhibitor) had no effect." @default.
- W1544892465 created "2016-06-24" @default.
- W1544892465 creator A5038695859 @default.
- W1544892465 creator A5040680632 @default.
- W1544892465 creator A5075795115 @default.
- W1544892465 date "1995-01-01" @default.
- W1544892465 modified "2023-09-27" @default.
- W1544892465 title "Chapter 11 Some new mechanisms underlying the actions of(–)-deprenyl: possible relevance to neurodegeneration" @default.
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