FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544926165> ?p ?o ?g. }

• W1544926165 endingPage "27" @default.
• W1544926165 startingPage "19" @default.
• W1544926165 abstract "Nucleoside reverse transcriptase inhibitors (NRTIs) plasma concentrations do not correlate with clinical efficacy or toxicity. These agents need to be phosphorylated to become active against HIV-infection. Thus, the characterization of the NRTIs intracellular metabolite pharmacological parameters will provide a better understanding that could lead to the development of more rational dose regimens in the HIV-infected population. Furthermore, intracellular measurements of NRTIs may provide a better marker with respect to clinical efficacy and toxicity than plasma concentrations. Thus, in this article we review the latest information regarding the intracellular pharmacological parameters of zidovudine (ZDV) and lamivudine (3TC) active metabolites in HIV-infected patients including the results from our recent clinical studies. We will start the discussion with ZDV and 3TC clinical efficacy, followed by systemic pharmacokinetics studies. We will then discuss the in vitro and in vivo intracellular studies with particular emphasis in the method development to measure these metabolites and we will conclude with the most current data from our clinical trials." @default.
• W1544926165 created "2016-06-24" @default.
• W1544926165 creator A5004267463 @default.
• W1544926165 creator A5005613479 @default.
• W1544926165 creator A5012552931 @default.
• W1544926165 creator A5032224704 @default.
• W1544926165 creator A5044072345 @default.
• W1544926165 creator A5049212958 @default.
• W1544926165 creator A5059226028 @default.
• W1544926165 creator A5073193640 @default.
• W1544926165 date "2000-03-01" @default.
• W1544926165 modified "2023-10-01" @default.
• W1544926165 title "Intracellular studies of the nucleoside reverse transcriptase inhibitor active metabolites: a review." @default.
• W1544926165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10761201" @default.
• W1544926165 hasPublicationYear "2000" @default.
• W1544926165 type Work @default.
• W1544926165 sameAs 1544926165 @default.
• W1544926165 citedByCount "4" @default.
• W1544926165 crossrefType "journal-article" @default.
• W1544926165 hasAuthorship W1544926165A5004267463 @default.
• W1544926165 hasAuthorship W1544926165A5005613479 @default.
• W1544926165 hasAuthorship W1544926165A5012552931 @default.
• W1544926165 hasAuthorship W1544926165A5032224704 @default.
• W1544926165 hasAuthorship W1544926165A5044072345 @default.
• W1544926165 hasAuthorship W1544926165A5049212958 @default.
• W1544926165 hasAuthorship W1544926165A5059226028 @default.
• W1544926165 hasAuthorship W1544926165A5073193640 @default.
• W1544926165 hasConcept C112705442 @default.
• W1544926165 hasConcept C126322002 @default.
• W1544926165 hasConcept C142462285 @default.
• W1544926165 hasConcept C149151106 @default.
• W1544926165 hasConcept C150903083 @default.
• W1544926165 hasConcept C159047783 @default.
• W1544926165 hasConcept C207001950 @default.
• W1544926165 hasConcept C2522874641 @default.
• W1544926165 hasConcept C2776543447 @default.
• W1544926165 hasConcept C2777333352 @default.
• W1544926165 hasConcept C2777351918 @default.
• W1544926165 hasConcept C2777477808 @default.
• W1544926165 hasConcept C2777869810 @default.
• W1544926165 hasConcept C2780216070 @default.
• W1544926165 hasConcept C2780593183 @default.
• W1544926165 hasConcept C2780727368 @default.
• W1544926165 hasConcept C2908647359 @default.
• W1544926165 hasConcept C2909970146 @default.
• W1544926165 hasConcept C29730261 @default.
• W1544926165 hasConcept C2993143319 @default.
• W1544926165 hasConcept C3013748606 @default.
• W1544926165 hasConcept C535046627 @default.
• W1544926165 hasConcept C55493867 @default.
• W1544926165 hasConcept C71924100 @default.
• W1544926165 hasConcept C79879829 @default.
• W1544926165 hasConcept C86803240 @default.
• W1544926165 hasConcept C98274493 @default.
• W1544926165 hasConcept C99454951 @default.
• W1544926165 hasConceptScore W1544926165C112705442 @default.
• W1544926165 hasConceptScore W1544926165C126322002 @default.
• W1544926165 hasConceptScore W1544926165C142462285 @default.
• W1544926165 hasConceptScore W1544926165C149151106 @default.
• W1544926165 hasConceptScore W1544926165C150903083 @default.
• W1544926165 hasConceptScore W1544926165C159047783 @default.
• W1544926165 hasConceptScore W1544926165C207001950 @default.
• W1544926165 hasConceptScore W1544926165C2522874641 @default.
• W1544926165 hasConceptScore W1544926165C2776543447 @default.
• W1544926165 hasConceptScore W1544926165C2777333352 @default.
• W1544926165 hasConceptScore W1544926165C2777351918 @default.
• W1544926165 hasConceptScore W1544926165C2777477808 @default.
• W1544926165 hasConceptScore W1544926165C2777869810 @default.
• W1544926165 hasConceptScore W1544926165C2780216070 @default.
• W1544926165 hasConceptScore W1544926165C2780593183 @default.
• W1544926165 hasConceptScore W1544926165C2780727368 @default.
• W1544926165 hasConceptScore W1544926165C2908647359 @default.
• W1544926165 hasConceptScore W1544926165C2909970146 @default.
• W1544926165 hasConceptScore W1544926165C29730261 @default.
• W1544926165 hasConceptScore W1544926165C2993143319 @default.
• W1544926165 hasConceptScore W1544926165C3013748606 @default.
• W1544926165 hasConceptScore W1544926165C535046627 @default.
• W1544926165 hasConceptScore W1544926165C55493867 @default.
• W1544926165 hasConceptScore W1544926165C71924100 @default.
• W1544926165 hasConceptScore W1544926165C79879829 @default.
• W1544926165 hasConceptScore W1544926165C86803240 @default.
• W1544926165 hasConceptScore W1544926165C98274493 @default.
• W1544926165 hasConceptScore W1544926165C99454951 @default.
• W1544926165 hasIssue "1" @default.
• W1544926165 hasLocation W15449261651 @default.
• W1544926165 hasOpenAccess W1544926165 @default.
• W1544926165 hasPrimaryLocation W15449261651 @default.
• W1544926165 hasRelatedWork W1536454324 @default.
• W1544926165 hasRelatedWork W1544926165 @default.
• W1544926165 hasRelatedWork W1590925586 @default.
• W1544926165 hasRelatedWork W1993848347 @default.
• W1544926165 hasRelatedWork W2088781853 @default.
• W1544926165 hasRelatedWork W2131729437 @default.
• W1544926165 hasRelatedWork W2135434805 @default.
• W1544926165 hasRelatedWork W2159169871 @default.
• W1544926165 hasRelatedWork W2172250655 @default.
• W1544926165 hasRelatedWork W3209748186 @default.
• W1544926165 hasVolume "19" @default.

• next