FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1544932316> ?p ?o ?g. }

• W1544932316 abstract "Medical research involving human subjects is invaluable for answering both scientific and clinical questions, notably those centred on making medical intervention as effective and safe as possible. But it raises a number of difficult moral issues: such experimentation can impose risk, questions arise about the adequacy of informed consent, and clinical research creates a tension between the roles of clinical therapist and research scientist. Many of these are encapsulated in the various regulations that exist – this article focuses on the guidelines for the United States – so part of what is required to be an ethical researcher is an understanding of these regulations, but it also requires ethical reasoning about such issues as informed consent, confidentiality, randomisation, placebos, vulnerable populations and special issues that arise in research across national boundaries.Key Concepts: A data and safety monitoring board (DSMB) is a committee set up for a given trial, independent from the researchers, which monitors (unblended) data as they accumulate, so as to make judgements about changes in the study including recommending early termination of the study.Informed consent is the fundamental (legal and ethical) requirement that a human subject give his or her voluntary and informed consent before being subject to research.An institutional review board (IRB) is a committee given the responsibility for approving or rejecting research protocols to be carried out within a given institution (such as a hospital or university).Randomized clinical trials (RCTs) are studies where participants are assigned by chance to receive one or another clinical intervention, thus controlling for the effect of other variables.Equipoise is the situation where there is no way to judge the difference between values of the different arms of a clinical trial, and it is often said that this must obtain to ensure the ethical acceptabilty of the trial.Keywords:regulations;informed consent;experimental treatment;clinical trial;equipoise" @default.
• W1544932316 created "2016-06-24" @default.
• W1544932316 creator A5021654216 @default.
• W1544932316 date "2014-09-15" @default.
• W1544932316 modified "2023-09-24" @default.
• W1544932316 title "Ethics of Research: Protection of Human Subjects" @default.
• W1544932316 cites W1972096363 @default.
• W1544932316 cites W1995148143 @default.
• W1544932316 cites W1995350918 @default.
• W1544932316 cites W1998045956 @default.
• W1544932316 cites W2121671594 @default.
• W1544932316 cites W2150060517 @default.
• W1544932316 cites W2165845288 @default.
• W1544932316 cites W2251419129 @default.
• W1544932316 cites W2465256481 @default.
• W1544932316 cites W2972709451 @default.
• W1544932316 cites W4211047340 @default.
• W1544932316 cites W4230159049 @default.
• W1544932316 doi "https://doi.org/10.1002/9780470015902.a0003482.pub3" @default.
• W1544932316 hasPublicationYear "2014" @default.
• W1544932316 type Work @default.
• W1544932316 sameAs 1544932316 @default.
• W1544932316 citedByCount "0" @default.
• W1544932316 crossrefType "reference-entry" @default.
• W1544932316 hasAuthorship W1544932316A5021654216 @default.
• W1544932316 hasConcept C118552586 @default.
• W1544932316 hasConcept C127413603 @default.
• W1544932316 hasConcept C142724271 @default.
• W1544932316 hasConcept C153997805 @default.
• W1544932316 hasConcept C15744967 @default.
• W1544932316 hasConcept C161191863 @default.
• W1544932316 hasConcept C177264268 @default.
• W1544932316 hasConcept C17744445 @default.
• W1544932316 hasConcept C199360897 @default.
• W1544932316 hasConcept C199539241 @default.
• W1544932316 hasConcept C204787440 @default.
• W1544932316 hasConcept C2775998707 @default.
• W1544932316 hasConcept C2776970089 @default.
• W1544932316 hasConcept C2777106319 @default.
• W1544932316 hasConcept C2777855551 @default.
• W1544932316 hasConcept C2780665704 @default.
• W1544932316 hasConcept C2992130261 @default.
• W1544932316 hasConcept C3116431 @default.
• W1544932316 hasConcept C41008148 @default.
• W1544932316 hasConcept C502991105 @default.
• W1544932316 hasConcept C509550671 @default.
• W1544932316 hasConcept C535046627 @default.
• W1544932316 hasConcept C55587333 @default.
• W1544932316 hasConcept C68122502 @default.
• W1544932316 hasConcept C71745522 @default.
• W1544932316 hasConcept C71924100 @default.
• W1544932316 hasConceptScore W1544932316C118552586 @default.
• W1544932316 hasConceptScore W1544932316C127413603 @default.
• W1544932316 hasConceptScore W1544932316C142724271 @default.
• W1544932316 hasConceptScore W1544932316C153997805 @default.
• W1544932316 hasConceptScore W1544932316C15744967 @default.
• W1544932316 hasConceptScore W1544932316C161191863 @default.
• W1544932316 hasConceptScore W1544932316C177264268 @default.
• W1544932316 hasConceptScore W1544932316C17744445 @default.
• W1544932316 hasConceptScore W1544932316C199360897 @default.
• W1544932316 hasConceptScore W1544932316C199539241 @default.
• W1544932316 hasConceptScore W1544932316C204787440 @default.
• W1544932316 hasConceptScore W1544932316C2775998707 @default.
• W1544932316 hasConceptScore W1544932316C2776970089 @default.
• W1544932316 hasConceptScore W1544932316C2777106319 @default.
• W1544932316 hasConceptScore W1544932316C2777855551 @default.
• W1544932316 hasConceptScore W1544932316C2780665704 @default.
• W1544932316 hasConceptScore W1544932316C2992130261 @default.
• W1544932316 hasConceptScore W1544932316C3116431 @default.
• W1544932316 hasConceptScore W1544932316C41008148 @default.
• W1544932316 hasConceptScore W1544932316C502991105 @default.
• W1544932316 hasConceptScore W1544932316C509550671 @default.
• W1544932316 hasConceptScore W1544932316C535046627 @default.
• W1544932316 hasConceptScore W1544932316C55587333 @default.
• W1544932316 hasConceptScore W1544932316C68122502 @default.
• W1544932316 hasConceptScore W1544932316C71745522 @default.
• W1544932316 hasConceptScore W1544932316C71924100 @default.
• W1544932316 hasLocation W15449323161 @default.
• W1544932316 hasOpenAccess W1544932316 @default.
• W1544932316 hasPrimaryLocation W15449323161 @default.
• W1544932316 hasRelatedWork W1545151610 @default.
• W1544932316 hasRelatedWork W194276753 @default.
• W1544932316 hasRelatedWork W1975828050 @default.
• W1544932316 hasRelatedWork W197824563 @default.
• W1544932316 hasRelatedWork W1986683187 @default.
• W1544932316 hasRelatedWork W2028981834 @default.
• W1544932316 hasRelatedWork W2045243665 @default.
• W1544932316 hasRelatedWork W2060681359 @default.
• W1544932316 hasRelatedWork W2068597553 @default.
• W1544932316 hasRelatedWork W2076398369 @default.
• W1544932316 hasRelatedWork W2077386955 @default.
• W1544932316 hasRelatedWork W2088693609 @default.
• W1544932316 hasRelatedWork W2104588631 @default.
• W1544932316 hasRelatedWork W2134999578 @default.
• W1544932316 hasRelatedWork W2140366916 @default.
• W1544932316 hasRelatedWork W2201343545 @default.
• W1544932316 hasRelatedWork W2373726732 @default.
• W1544932316 hasRelatedWork W2593814322 @default.
• W1544932316 hasRelatedWork W2903214213 @default.
• W1544932316 hasRelatedWork W3208830670 @default.

• next