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• W1545198659 abstract "textabstractIn the last decade the primary treatment of laryngeal and hypopharyngeal cancer was shifted towards organ preservation, i.e. preservation of the larynx. The treatment of laryngeal cancer was changed from standard radiotherapy towards hyperfractionated radiotherapy. Hypopharyngeal cancer is nowadays mostly treated with a combination of chemotherapy and radiotherapy instead of primary surgery. Therefore, the greatest shift in treatment protocols found was for hypopharyngeal cancer. The goal of this thesis was in the first place to find out whether recurrent laryngeal cancer can be treated with preservation of the larynx and the consequences of organ preservation for the function of the “new” organ. The second goal of this thesis was to find out which treatment protocols are used in the Netherlands for hypopharyngeal cancer. Also, to find the consequences of chemoradiation protocols for surgical treatment of recurrent hypopharyngeal cancer.Chapter I is a general introduction of laryngeal and hypopharyngeal cancer. The incidences of laryngeal and hypopharyngeal cancer are mentioned. Furthermore, the biggest risk factors, being smoking and alcohol, are described. Especially, the effect of tobacco smoke on the development of laryngeal and hypopharyngeal cancer is described. Tobacco smoke contains several substances, which can cause mutations in genes. The mutations deregulate several enzyme systems and cell regulation systems, which cause degeneration of squamous cell epithelium. An overview of the other chapters of this thesis is given.In Chapter II two partial laryngectomy techniques are described. The oncological and functional results of the endoscopic CO2 laser and the frontolateral partial laryngectomy for the treatment of the recurrent glottic laryngeal cancer are described. The indications of both techniques are mentioned. Both techniques have good oncological results and less functional problems were found. With the CO2 laser 44-58% of the patients are cured with preservation of the larynx; with the frontolateral partial laryngectomy 71% was cured. It is important to realize that in case of a new recurrence, a total laryngectomy can be performed without an extra risk of failure for therapy. Both partial laryngectomy techniques, CO2 laser and frontolateral partial laryngectomy, are good treatment modalities for recurrent glottic laryngeal cancer. However, the indications for the different techniques are important and should be followed strictly.In chapter III the functional and oncological results of the third partial laryngectomy technique, cricohyoidoepiglottopexy (CHEP), is described. With the CHEP 79% of the patients are cured with preservation of the larynx. In eight patients a Flexible Endoscopic Evaluation of Swallowing (FEES) was performed to objectify problems swallowing. In none of the patients aspiration was found. Before and after the operation the voice was recorded and judged. After the operation the voice is worst. However, most patients are satisfied with there voice. The CHEP appears oncologically safe and functional for the treatment of recurrent glottic laryngeal cancer in selected patients.In chapter IV was investigated whether the quality of life is different after a partial laryngectomy versus a total laryngectomy for recurrent laryngeal carcinomas after radiotherapy. Also the voice of both groups of patients was judged. The quality of life was investigated with the EORTC Quality of Life Questionnaire (QLQ) – C30 Dutch version 3.0 and the EORTC – H & N 35 questionnaire. The only difference found was smell and taste related. The voice was judged with the Voice Handicap Index. No differences between the two groups were found. There are no big differences in quality of life after treatment with a partial or a total laryngectomy. This is mainly caused by the unexpected good quality of life after a total laryngectomy.In chapter V the treatment of hypopharyngeal cancer in the Netherlands is described. The treatment of hypopharyngeal cancer in the period 1985 – 1994 was investigated. The biggest group of patients was treated with radiotherapy alone or with combined radiotherapy and surgery. The overall 5-year disease-free survival after treatment with curative intention was 32%. The disease-free survival is better after combined surgery and radiotherapy.In chapter VI, the complications after salvage surgery in patients prior treated with radiotherapy alone or chemoradiation is described. The post-operative complication rate is significantly higher (92% vs. 50%) in the chemoradiation group. The most frequent complication found was a pharygocutaneous fistula. The quality of life, after a longer post-operative period, showed a significant difference in social functioning in disadvantage of the chemoradiation group.In the general discussion (chapter VII) the found results are discussed. The most important conclusion is that there is place for organ preservation therapy, but we must remain critical of indications and side effects of organ preservation protocols while we should realize that quality of life after total laryngectomy are not as poor as we might sometimes think." @default.
• W1545198659 created "2016-06-24" @default.
• W1545198659 creator A5054970394 @default.
• W1545198659 date "2006-05-17" @default.
• W1545198659 modified "2023-09-27" @default.
• W1545198659 title "Preservation of the Larynx in Laryngeal and Hypopharyngeal Cancer" @default.
• W1545198659 cites W1531252636 @default.
• W1545198659 cites W1843373062 @default.
• W1545198659 cites W1854220427 @default.
• W1545198659 cites W1964241133 @default.
• W1545198659 cites W1967714521 @default.
• W1545198659 cites W1968741994 @default.
• W1545198659 cites W1970342053 @default.
• W1545198659 cites W1973228651 @default.
• W1545198659 cites W1976774278 @default.
• W1545198659 cites W1978937337 @default.
• W1545198659 cites W1986439527 @default.
• W1545198659 cites W1988998183 @default.
• W1545198659 cites W1994259469 @default.
• W1545198659 cites W1996545888 @default.
• W1545198659 cites W1996901136 @default.
• W1545198659 cites W1998864441 @default.
• W1545198659 cites W1998971416 @default.
• W1545198659 cites W1999983422 @default.
• W1545198659 cites W2001576219 @default.
• W1545198659 cites W2004240374 @default.
• W1545198659 cites W2005343456 @default.
• W1545198659 cites W2006987762 @default.
• W1545198659 cites W2010338406 @default.
• W1545198659 cites W2022025986 @default.
• W1545198659 cites W2022395184 @default.
• W1545198659 cites W2026193724 @default.
• W1545198659 cites W2026478192 @default.
• W1545198659 cites W2030806493 @default.
• W1545198659 cites W2033563842 @default.
• W1545198659 cites W2034659769 @default.
• W1545198659 cites W2040017960 @default.
• W1545198659 cites W2040086880 @default.
• W1545198659 cites W2041562902 @default.
• W1545198659 cites W2042332526 @default.
• W1545198659 cites W2042860351 @default.
• W1545198659 cites W2050099184 @default.
• W1545198659 cites W2051625011 @default.
• W1545198659 cites W2051747377 @default.
• W1545198659 cites W2054096550 @default.
• W1545198659 cites W2057201155 @default.
• W1545198659 cites W2057796267 @default.
• W1545198659 cites W2058902345 @default.
• W1545198659 cites W2064204667 @default.
• W1545198659 cites W2064584683 @default.
• W1545198659 cites W2066742209 @default.
• W1545198659 cites W2073915353 @default.
• W1545198659 cites W2074432834 @default.
• W1545198659 cites W2089729690 @default.
• W1545198659 cites W2094780093 @default.
• W1545198659 cites W2095069901 @default.
• W1545198659 cites W2100961085 @default.
• W1545198659 cites W2101254963 @default.
• W1545198659 cites W2104438489 @default.
• W1545198659 cites W2104460470 @default.
• W1545198659 cites W2120404243 @default.
• W1545198659 cites W2123266829 @default.
• W1545198659 cites W2136225306 @default.
• W1545198659 cites W2136253833 @default.
• W1545198659 cites W2146552670 @default.
• W1545198659 cites W2152609192 @default.
• W1545198659 cites W2153697276 @default.
• W1545198659 cites W2159550651 @default.
• W1545198659 cites W2163040515 @default.
• W1545198659 cites W2167571044 @default.
• W1545198659 cites W2169657533 @default.
• W1545198659 cites W2313331488 @default.
• W1545198659 cites W2315338729 @default.
• W1545198659 cites W2315741257 @default.
• W1545198659 cites W2315754739 @default.
• W1545198659 cites W2322660172 @default.
• W1545198659 cites W2328321491 @default.
• W1545198659 cites W2413799329 @default.
• W1545198659 cites W2414302766 @default.
• W1545198659 cites W2417385965 @default.
• W1545198659 cites W2471046715 @default.
• W1545198659 cites W2562414697 @default.
• W1545198659 cites W2891423939 @default.
• W1545198659 cites W2973515423 @default.
• W1545198659 cites W3023721602 @default.
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