FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545282597> ?p ?o ?g. }

• W1545282597 abstract "How does the brain control coordinated movements? It is known that many brain regions (i.e., motor cortex, supplementary motor area, cerebellum, and basal ganglia) are active during movement, but it is not completely understood how these regions interact, what the precise functional responsibility is for each region, and why certain regions are active only for certain tasks. In patients afflicted with a motor disease or injured by stroke, simple tasks such as reaching for a mug of coffee to take a sip become difficult, often requiring intense concentration by the patient.The basal ganglia are a collection of subcortical structures which form part of a motor loop. Cortical input is processed by the basal ganglia and forwarded back to the cortex via the thalamus. Parkinson's disease, characterized by the substantive reduction in dopamine within the basal ganglia's substantia nigra pars compacta and the degeneration of the nigrostriatal pathway, produces such physical disabilities as akinesia, difficulty in initiating movement, slowness of movement execution, and a rhythmical tremor at rest. Parkinson's disease patients may also have difficulties in performing a sequence of movements, and may exhibit pauses between the movements. Based upon clinical data from kinematic studies, cellular recordings, and positron emission tomography (PET), we hypothesize the basal ganglia have two main functions: the inhibition of movement and the provision of next sensory state information to cortex. Further, we suggest that the indirect pathway of the basal ganglia is responsible for movement inhibition, while the direct pathway is involved with next sensory state information. To support our hypothesis, we present three models of basal ganglia function during arm movement which illustrate how the basal ganglia contribute to motor control, and how disabling the region via the loss of dopamine disturbs normal motor function." @default.
• W1545282597 created "2016-06-24" @default.
• W1545282597 creator A5009909957 @default.
• W1545282597 date "1998-01-01" @default.
• W1545282597 modified "2023-09-24" @default.
• W1545282597 title "Modeling the basal ganglia in the control of arm movements" @default.
• W1545282597 cites W100742014 @default.
• W1545282597 cites W120040297 @default.
• W1545282597 cites W1256954504 @default.
• W1545282597 cites W143324445 @default.
• W1545282597 cites W1497648884 @default.
• W1545282597 cites W1510847502 @default.
• W1545282597 cites W1513126258 @default.
• W1545282597 cites W1549910234 @default.
• W1545282597 cites W1554149631 @default.
• W1545282597 cites W1559420469 @default.
• W1545282597 cites W1566901376 @default.
• W1545282597 cites W1586994437 @default.
• W1545282597 cites W1607774347 @default.
• W1545282597 cites W160972202 @default.
• W1545282597 cites W1669834713 @default.
• W1545282597 cites W1685150300 @default.
• W1545282597 cites W1748759529 @default.
• W1545282597 cites W175938201 @default.
• W1545282597 cites W1768450208 @default.
• W1545282597 cites W1774047354 @default.
• W1545282597 cites W1776005331 @default.
• W1545282597 cites W1780332285 @default.
• W1545282597 cites W179204262 @default.
• W1545282597 cites W1799331832 @default.
• W1545282597 cites W1810663112 @default.
• W1545282597 cites W1815501369 @default.
• W1545282597 cites W1871190058 @default.
• W1545282597 cites W1883604772 @default.
• W1545282597 cites W1890315254 @default.
• W1545282597 cites W1892385946 @default.
• W1545282597 cites W1897438103 @default.
• W1545282597 cites W1907481827 @default.
• W1545282597 cites W1964309638 @default.
• W1545282597 cites W1965200637 @default.
• W1545282597 cites W1965602459 @default.
• W1545282597 cites W1965689543 @default.
• W1545282597 cites W1969271919 @default.
• W1545282597 cites W1972778950 @default.
• W1545282597 cites W1974183957 @default.
• W1545282597 cites W1975814998 @default.
• W1545282597 cites W1977208975 @default.
• W1545282597 cites W1977478110 @default.
• W1545282597 cites W1978459903 @default.
• W1545282597 cites W1979455727 @default.
• W1545282597 cites W1981553105 @default.
• W1545282597 cites W1982583848 @default.
• W1545282597 cites W1982827121 @default.
• W1545282597 cites W1984511977 @default.
• W1545282597 cites W1987277327 @default.
• W1545282597 cites W1988041026 @default.
• W1545282597 cites W1988762607 @default.
• W1545282597 cites W1991603311 @default.
• W1545282597 cites W1992587213 @default.
• W1545282597 cites W1992661004 @default.
• W1545282597 cites W1994336615 @default.
• W1545282597 cites W1998116113 @default.
• W1545282597 cites W1999014668 @default.
• W1545282597 cites W1999961963 @default.
• W1545282597 cites W2001579813 @default.
• W1545282597 cites W2001871185 @default.
• W1545282597 cites W2002314838 @default.
• W1545282597 cites W2003414509 @default.
• W1545282597 cites W2004996958 @default.
• W1545282597 cites W2005218321 @default.
• W1545282597 cites W2005269174 @default.
• W1545282597 cites W2005337916 @default.
• W1545282597 cites W2005783469 @default.
• W1545282597 cites W2008137931 @default.
• W1545282597 cites W2008274305 @default.
• W1545282597 cites W2009147637 @default.
• W1545282597 cites W2011733863 @default.
• W1545282597 cites W2015215114 @default.
• W1545282597 cites W2017562071 @default.
• W1545282597 cites W2019432365 @default.
• W1545282597 cites W2019977932 @default.
• W1545282597 cites W2020725648 @default.
• W1545282597 cites W2021181097 @default.
• W1545282597 cites W2022072305 @default.
• W1545282597 cites W2024124362 @default.
• W1545282597 cites W2025189913 @default.
• W1545282597 cites W2025788148 @default.
• W1545282597 cites W2025964028 @default.
• W1545282597 cites W2031170958 @default.
• W1545282597 cites W2033382270 @default.
• W1545282597 cites W2039862969 @default.
• W1545282597 cites W2041337335 @default.
• W1545282597 cites W2041659565 @default.
• W1545282597 cites W2043277419 @default.
• W1545282597 cites W2043313965 @default.
• W1545282597 cites W2048789521 @default.
• W1545282597 cites W2050381379 @default.
• W1545282597 cites W2054102932 @default.
• W1545282597 cites W2054549571 @default.
• W1545282597 cites W2055164620 @default.

• next