Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545303483> ?p ?o ?g. }
- W1545303483 endingPage "1292" @default.
- W1545303483 startingPage "1283" @default.
- W1545303483 abstract "Reduced nephron number predisposes to hypertension and kidney disease. Interaction of the branching ureteric bud and surrounding mesenchymal cells determines nephron number. Since oxygen supply may be critical for intrauterine development, we tested whether hypoxia and hypoxia-inducible factor-1α (HIF-1α) influence nephrogenesis. We found that HIF-1α is required for branching of MDCK cells. In addition, culture of metanephric mouse kidneys with ureteric bud cell-specific stabilization or knockout of HIF-1α revealed a positive impact of HIF-1α on nephrogenesis. In contrast, widespread stabilization of HIF-1α in metanephric kidneys through hypoxia or HIF stabilizers impaired nephrogenesis, and pharmacological HIF inhibition enhanced nephrogenesis. Several lines of evidence suggest an inhibitory effect through the hypoxia response of mesenchymal cells. HIF-1α was expressed in mesenchymal cells during nephrogenesis. Expression of the anti-branching factors Bmp4 and Vegfa, secreted by mesenchymal cells, was increased upon HIF stabilization. The conditioned medium from hypoxic metanephric kidneys inhibited MDCK branching, which was partially rescued by Vegfa antibodies. Thus, the effect of HIF-1α on nephrogenesis appears context dependent. While HIF-1α in the ureteric bud is of importance for proper branching morphogenesis, the net effect of hypoxia-induced HIF activation in the embryonic kidney appears to be mesenchymal cell-dependent inhibition of ureter branching." @default.
- W1545303483 created "2016-06-24" @default.
- W1545303483 creator A5001373461 @default.
- W1545303483 creator A5001850213 @default.
- W1545303483 creator A5010255326 @default.
- W1545303483 creator A5011388772 @default.
- W1545303483 creator A5016520268 @default.
- W1545303483 creator A5019699199 @default.
- W1545303483 creator A5026584082 @default.
- W1545303483 creator A5029262443 @default.
- W1545303483 creator A5032990574 @default.
- W1545303483 creator A5066841350 @default.
- W1545303483 creator A5085108722 @default.
- W1545303483 date "2015-12-01" @default.
- W1545303483 modified "2023-10-13" @default.
- W1545303483 title "Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis" @default.
- W1545303483 cites W1550989298 @default.
- W1545303483 cites W1966772525 @default.
- W1545303483 cites W1974586776 @default.
- W1545303483 cites W1977242675 @default.
- W1545303483 cites W1981154915 @default.
- W1545303483 cites W1985703337 @default.
- W1545303483 cites W1986340915 @default.
- W1545303483 cites W1989673353 @default.
- W1545303483 cites W1990964119 @default.
- W1545303483 cites W1995734429 @default.
- W1545303483 cites W2006644254 @default.
- W1545303483 cites W2009968854 @default.
- W1545303483 cites W2010131036 @default.
- W1545303483 cites W2018008610 @default.
- W1545303483 cites W2018701070 @default.
- W1545303483 cites W2019273089 @default.
- W1545303483 cites W2020598309 @default.
- W1545303483 cites W2022373071 @default.
- W1545303483 cites W2024564719 @default.
- W1545303483 cites W2026952469 @default.
- W1545303483 cites W2027519976 @default.
- W1545303483 cites W2028034677 @default.
- W1545303483 cites W2032002630 @default.
- W1545303483 cites W2038449972 @default.
- W1545303483 cites W2050964782 @default.
- W1545303483 cites W2054633892 @default.
- W1545303483 cites W2056919530 @default.
- W1545303483 cites W2057549159 @default.
- W1545303483 cites W2074415567 @default.
- W1545303483 cites W2082295977 @default.
- W1545303483 cites W2084176144 @default.
- W1545303483 cites W2091068407 @default.
- W1545303483 cites W2092806387 @default.
- W1545303483 cites W2095643982 @default.
- W1545303483 cites W2103073696 @default.
- W1545303483 cites W2112222526 @default.
- W1545303483 cites W2113656210 @default.
- W1545303483 cites W2114618700 @default.
- W1545303483 cites W2117287510 @default.
- W1545303483 cites W2117421779 @default.
- W1545303483 cites W2134312287 @default.
- W1545303483 cites W2134798084 @default.
- W1545303483 cites W2135705997 @default.
- W1545303483 cites W2138561620 @default.
- W1545303483 cites W2138657723 @default.
- W1545303483 cites W2143148074 @default.
- W1545303483 cites W2147307956 @default.
- W1545303483 cites W2154167701 @default.
- W1545303483 cites W2156628952 @default.
- W1545303483 cites W2160219683 @default.
- W1545303483 cites W2165019590 @default.
- W1545303483 cites W2170646136 @default.
- W1545303483 cites W2319994237 @default.
- W1545303483 doi "https://doi.org/10.1038/ki.2015.214" @default.
- W1545303483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26200943" @default.
- W1545303483 hasPublicationYear "2015" @default.
- W1545303483 type Work @default.
- W1545303483 sameAs 1545303483 @default.
- W1545303483 citedByCount "26" @default.
- W1545303483 countsByYear W15453034832015 @default.
- W1545303483 countsByYear W15453034832016 @default.
- W1545303483 countsByYear W15453034832017 @default.
- W1545303483 countsByYear W15453034832018 @default.
- W1545303483 countsByYear W15453034832019 @default.
- W1545303483 countsByYear W15453034832020 @default.
- W1545303483 countsByYear W15453034832022 @default.
- W1545303483 countsByYear W15453034832023 @default.
- W1545303483 crossrefType "journal-article" @default.
- W1545303483 hasAuthorship W1545303483A5001373461 @default.
- W1545303483 hasAuthorship W1545303483A5001850213 @default.
- W1545303483 hasAuthorship W1545303483A5010255326 @default.
- W1545303483 hasAuthorship W1545303483A5011388772 @default.
- W1545303483 hasAuthorship W1545303483A5016520268 @default.
- W1545303483 hasAuthorship W1545303483A5019699199 @default.
- W1545303483 hasAuthorship W1545303483A5026584082 @default.
- W1545303483 hasAuthorship W1545303483A5029262443 @default.
- W1545303483 hasAuthorship W1545303483A5032990574 @default.
- W1545303483 hasAuthorship W1545303483A5066841350 @default.
- W1545303483 hasAuthorship W1545303483A5085108722 @default.
- W1545303483 hasBestOaLocation W15453034831 @default.
- W1545303483 hasConcept C104317684 @default.
- W1545303483 hasConcept C126322002 @default.