FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545348542> ?p ?o ?g. }

• W1545348542 endingPage "216" @default.
• W1545348542 startingPage "202" @default.
• W1545348542 abstract "In contrast to other organs, the lung completes a significant portion of its development after term birth. During this stage of alveolarization, division of the alveolar ducts into alveolar sacs by secondary septation, and expansion of the pulmonary vasculature by means of angiogenesis markedly increase the gas exchange surface area of the lung. However, postnatal completion of growth renders the lung highly susceptible to environmental insults such as inflammation that disrupt this developmental program. This is particularly evident in the setting of preterm birth, where impairment of alveolarization causes bronchopulmonary dysplasia, a chronic lung disease associated with significant morbidity. The nuclear factor κ-B (NFκB) family of transcription factors are ubiquitously expressed, and function to regulate diverse cellular processes including proliferation, survival, and immunity. Extensive evidence suggests that activation of NFκB is important in the regulation of inflammation and in the control of angiogenesis. Therefore, NFκB-mediated downstream effects likely influence the lung response to injury and may also mediate normal alveolar development. This review summarizes the main biologic functions of NFκB, and highlights the regulatory mechanisms that allow for diversity and specificity in downstream gene activation. This is followed by a description of the pro and anti-inflammatory functions of NFκB in the lung, and of NFκB-mediated angiogenic effects. Finally, this review summarizes the clinical and experimental data that support a role for NFκB in mediating postnatal angiogenesis and alveolarization, and discusses the challenges that remain in developing therapies that can selectively block the detrimental functions of NFκB yet preserve the beneficial effects. Birth Defects Research (Part A) 100:202–216, 2014. © 2014 Wiley Periodicals, Inc." @default.
• W1545348542 created "2016-06-24" @default.
• W1545348542 creator A5060672186 @default.
• W1545348542 date "2014-03-01" @default.
• W1545348542 modified "2023-09-24" @default.
• W1545348542 title "Nuclear factor‐kappa‐B signaling in lung development and disease: One pathway, numerous functions" @default.
• W1545348542 cites W1484486338 @default.
• W1545348542 cites W1491499843 @default.
• W1545348542 cites W1501881225 @default.
• W1545348542 cites W1518302436 @default.
• W1545348542 cites W1545189970 @default.
• W1545348542 cites W1553110542 @default.
• W1545348542 cites W1558367558 @default.
• W1545348542 cites W1581220495 @default.
• W1545348542 cites W1593402425 @default.
• W1545348542 cites W159669330 @default.
• W1545348542 cites W1738317710 @default.
• W1545348542 cites W1763097477 @default.
• W1545348542 cites W1829577351 @default.
• W1545348542 cites W1883301416 @default.
• W1545348542 cites W1883928651 @default.
• W1545348542 cites W1888783223 @default.
• W1545348542 cites W1958512987 @default.
• W1545348542 cites W1962869168 @default.
• W1545348542 cites W1964294676 @default.
• W1545348542 cites W1965502287 @default.
• W1545348542 cites W1966828006 @default.
• W1545348542 cites W1969847452 @default.
• W1545348542 cites W1973390904 @default.
• W1545348542 cites W1976382352 @default.
• W1545348542 cites W1977090347 @default.
• W1545348542 cites W1977348907 @default.
• W1545348542 cites W1980119094 @default.
• W1545348542 cites W1982062664 @default.
• W1545348542 cites W1982776595 @default.
• W1545348542 cites W1983398917 @default.
• W1545348542 cites W1985469556 @default.
• W1545348542 cites W1986453396 @default.
• W1545348542 cites W1988644891 @default.
• W1545348542 cites W1988924112 @default.
• W1545348542 cites W1990674638 @default.
• W1545348542 cites W1991868611 @default.
• W1545348542 cites W1992841021 @default.
• W1545348542 cites W1992978140 @default.
• W1545348542 cites W1993216157 @default.
• W1545348542 cites W1993451325 @default.
• W1545348542 cites W1994331463 @default.
• W1545348542 cites W1996492588 @default.
• W1545348542 cites W1999982643 @default.
• W1545348542 cites W2000291787 @default.
• W1545348542 cites W2002674047 @default.
• W1545348542 cites W2003563563 @default.
• W1545348542 cites W2004966137 @default.
• W1545348542 cites W2005047699 @default.
• W1545348542 cites W2005177957 @default.
• W1545348542 cites W2006122359 @default.
• W1545348542 cites W2008145382 @default.
• W1545348542 cites W2008954476 @default.
• W1545348542 cites W2010237936 @default.
• W1545348542 cites W2012818083 @default.
• W1545348542 cites W2014518336 @default.
• W1545348542 cites W2015492017 @default.
• W1545348542 cites W2018718597 @default.
• W1545348542 cites W2019786488 @default.
• W1545348542 cites W2022895499 @default.
• W1545348542 cites W2024470090 @default.
• W1545348542 cites W2024716223 @default.
• W1545348542 cites W2025283490 @default.
• W1545348542 cites W2026615227 @default.
• W1545348542 cites W2027154318 @default.
• W1545348542 cites W2032531389 @default.
• W1545348542 cites W2033810895 @default.
• W1545348542 cites W2038554369 @default.
• W1545348542 cites W2041186477 @default.
• W1545348542 cites W2042267093 @default.
• W1545348542 cites W2042832398 @default.
• W1545348542 cites W2043892945 @default.
• W1545348542 cites W2044608904 @default.
• W1545348542 cites W2046219308 @default.
• W1545348542 cites W2052908553 @default.
• W1545348542 cites W2053372168 @default.
• W1545348542 cites W2062979901 @default.
• W1545348542 cites W2065029194 @default.
• W1545348542 cites W2067161281 @default.
• W1545348542 cites W2067265556 @default.
• W1545348542 cites W2067938485 @default.
• W1545348542 cites W2073543023 @default.
• W1545348542 cites W2073741182 @default.
• W1545348542 cites W2074290972 @default.
• W1545348542 cites W2090594538 @default.
• W1545348542 cites W2091360431 @default.
• W1545348542 cites W2093713190 @default.
• W1545348542 cites W2096552213 @default.
• W1545348542 cites W2096589599 @default.
• W1545348542 cites W2104331475 @default.
• W1545348542 cites W2104642638 @default.
• W1545348542 cites W2105828774 @default.
• W1545348542 cites W2106503814 @default.

• next