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- W1545469100 abstract "The efficiency and usefulness of oral cisplatin using sustained-release cisplatin solid dispersions was studied in tumour-loaded mice.Mice were inoculated intraperitoneally with P815 tumour cells, before treatment with 10 mg kg−1 cisplatin. Cisplatin solid dispersions were suspended in 1% sodium carboxy-methylcellulose and administered according to seven therapeutic schedules. Group A received one dose on day 1; B, daily doses on days 1, 2 and 3; C, daily doses on days 1, 3 and 5; D, daily doses on days 1, 2, 3, 4 and 5; E, daily doses on days 1, 3, 5, 7 and 9; F, daily doses on days 1, 2, 3, 4, 5, 6 and 7; G, daily doses on days 1, 3, 5, 7, 9, 11 and 13. Control mice received a solid dispersion not loaded with cisplatin and reference mice received 10 mg kg−1 cisplatin in solution. Mean survival times were significantly increased in groups D, E, F and G compared with control and reference mice (13.6±0.2, 9.5±0.8, 16.1±0.3; 13.8±0.2, 11.1±0.8, 15.0±0.5; 13.4±0.2, 7.6±0.2, 16.1±0.3; 13.3±0.2, 11.0±0.9, 15.9±0.3 days for control, reference and cisplatin solid dispersion, respectively). Toxicokinetic studies were performed in another three groups of mice receiving 10 mg kg−1 cisplatin solid dispersion daily for five and seven doses and every 2 days for a total of seven doses. The base and the peak serum cisplatin concentrations were measured by atomic absorption and were within the therapeutic range for cisplatin (0.2–1.0 μg mL−1).The results suggest the efficiency and usefulness of oral cisplatin therapy with sustained-release cisplatin solid dispersions in the tumour-transplanted mouse model." @default.
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- W1545469100 date "1998-12-01" @default.
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- W1545469100 title "Antitumour Activity of Oral Sustained‐release Cisplatin Solid Dispersions in Tumour‐transplanted Mice" @default.
- W1545469100 doi "https://doi.org/10.1111/j.2042-7158.1998.tb00677.x" @default.
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