FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545616820> ?p ?o ?g. }

• W1545616820 abstract "Driven by global competition and rising cost pressure in the pharmaceutical industry, over the last ten years single-use bioreactors have been increasingly used for animal cell cultivations in screening experiments, seed inoculum and seed train productions as well as in small and medium scale production processes of proteins (in particular, antibodies and vaccines). In contrast to re-usable bioreactors made of glass or stainless steel, single-use bioreactors consist of a flexible or rigid cultivation vessel which has been gamma-sterilized and made ready for the purchaser to use. After harvest, the cultivation vessel is discarded, which results in a lower risk of cross-contamination, and eliminates the need for steam sterilization and cleaning [Eibl et al. (2010)]. Nowadays a multitude of single-use bioreactors are commercially available, which can be categorized according to the type of power input into static and dynamic systems. The latter can be further subdivided into hydraulically, pneumatically and mechanically driven bioreactors and their combinations, the so-called hybrid systems [Eibl et al. (2011)]. Mechanically driven single-use bioreactors represent the largest group and are mixed by either orbital-shaken, wave-induced or stirrer motion. While wave-mixed bioreactors (e.g. from GE Healthcare, Sartorius Stedim Biotech, Applikon Biotechnology) were initially dominant, nowadays stirred bag systems (such as Hyclone® Single Use Bioreactor S.U.B., BIOSTAT® CultiBag STR, XDRTM-DSTB animal) are more frequently used, mainly due to the broad experience already obtained with conventional stirred cell culture bioreactors [Eibl et al. (2011)]. The flexible cultivation bags are fixed and shaped by a temperature-controlled stainless steel container. This design is also used in the BIOSTAT® CultiBag STR from Sartorius Stedim Biotech, which is available at different scales from 50 to 1,000 L. The bag geometry, the impellers and the aeration system are designed in a similar way to Sartorius Stedim’s re-usable stirred cell culture bioreactors to ensure comparability of single-use and classical processes, and thus facilitate integration of singleuse bioreactor technologies into modern cultivation processes [De Wilde et al. (2009); Noack et al. (2011)]. Until summer 2009, stirred bag bioreactors were available only at working volumes exceeding 50 L for manufacturing and cost reasons. The introduction of the first single-use stirred bioreactors with a rigid cultivation vessel (Mobius® CellReady 3L bioreactor and CelliGen® BLU SUB) bridged the gap for stirred systems between laboratory and pilot scale" @default.
• W1545616820 created "2016-06-24" @default.
• W1545616820 creator A5012755492 @default.
• W1545616820 creator A5020197959 @default.
• W1545616820 creator A5045466490 @default.
• W1545616820 creator A5058324074 @default.
• W1545616820 date "2011-07-05" @default.
• W1545616820 modified "2023-10-17" @default.
• W1545616820 title "CFD for Characterizing Standard and Single-use Stirred Cell Culture Bioreactors" @default.
• W1545616820 cites W1563679736 @default.
• W1545616820 cites W1587689022 @default.
• W1545616820 cites W1902419741 @default.
• W1545616820 cites W1964426143 @default.
• W1545616820 cites W1964768285 @default.
• W1545616820 cites W1965876945 @default.
• W1545616820 cites W1967089156 @default.
• W1545616820 cites W1970403495 @default.
• W1545616820 cites W1973220533 @default.
• W1545616820 cites W1973624122 @default.
• W1545616820 cites W1974225897 @default.
• W1545616820 cites W1977258735 @default.
• W1545616820 cites W1978194746 @default.
• W1545616820 cites W1978659446 @default.
• W1545616820 cites W1983477509 @default.
• W1545616820 cites W1986435000 @default.
• W1545616820 cites W1987392497 @default.
• W1545616820 cites W1992912322 @default.
• W1545616820 cites W1993950717 @default.
• W1545616820 cites W1995602692 @default.
• W1545616820 cites W2009750081 @default.
• W1545616820 cites W2014724114 @default.
• W1545616820 cites W2015481043 @default.
• W1545616820 cites W2017953056 @default.
• W1545616820 cites W2019907023 @default.
• W1545616820 cites W2027630798 @default.
• W1545616820 cites W2027803202 @default.
• W1545616820 cites W2040312499 @default.
• W1545616820 cites W2050338607 @default.
• W1545616820 cites W2058406640 @default.
• W1545616820 cites W2059871184 @default.
• W1545616820 cites W2066798086 @default.
• W1545616820 cites W2073040061 @default.
• W1545616820 cites W2078188206 @default.
• W1545616820 cites W2078412313 @default.
• W1545616820 cites W2078484967 @default.
• W1545616820 cites W2080823019 @default.
• W1545616820 cites W2080826463 @default.
• W1545616820 cites W2082916114 @default.
• W1545616820 cites W2098829286 @default.
• W1545616820 cites W2099649939 @default.
• W1545616820 cites W2114879349 @default.
• W1545616820 cites W2130870013 @default.
• W1545616820 cites W2139254959 @default.
• W1545616820 cites W2152267869 @default.
• W1545616820 cites W2153492345 @default.
• W1545616820 cites W2161226422 @default.
• W1545616820 cites W2168834542 @default.
• W1545616820 cites W2170734651 @default.
• W1545616820 cites W2171128944 @default.
• W1545616820 cites W2171591058 @default.
• W1545616820 cites W2207292378 @default.
• W1545616820 cites W231834401 @default.
• W1545616820 cites W2342166896 @default.
• W1545616820 cites W2469535567 @default.
• W1545616820 cites W2476040219 @default.
• W1545616820 cites W2479932804 @default.
• W1545616820 cites W2498751607 @default.
• W1545616820 cites W62193260 @default.
• W1545616820 cites W2145497887 @default.
• W1545616820 cites W3145780045 @default.
• W1545616820 cites W328664014 @default.
• W1545616820 doi "https://doi.org/10.5772/23496" @default.
• W1545616820 hasPublicationYear "2011" @default.
• W1545616820 type Work @default.
• W1545616820 sameAs 1545616820 @default.
• W1545616820 citedByCount "9" @default.
• W1545616820 countsByYear W15456168202013 @default.
• W1545616820 countsByYear W15456168202014 @default.
• W1545616820 countsByYear W15456168202015 @default.
• W1545616820 countsByYear W15456168202017 @default.
• W1545616820 countsByYear W15456168202018 @default.
• W1545616820 countsByYear W15456168202019 @default.
• W1545616820 countsByYear W15456168202021 @default.
• W1545616820 countsByYear W15456168202023 @default.
• W1545616820 crossrefType "book-chapter" @default.
• W1545616820 hasAuthorship W1545616820A5012755492 @default.
• W1545616820 hasAuthorship W1545616820A5020197959 @default.
• W1545616820 hasAuthorship W1545616820A5045466490 @default.
• W1545616820 hasAuthorship W1545616820A5058324074 @default.
• W1545616820 hasBestOaLocation W15456168201 @default.
• W1545616820 hasConcept C127413603 @default.
• W1545616820 hasConcept C146978453 @default.
• W1545616820 hasConcept C1633027 @default.
• W1545616820 hasConcept C168170006 @default.
• W1545616820 hasConcept C178790620 @default.
• W1545616820 hasConcept C183696295 @default.
• W1545616820 hasConcept C185592680 @default.
• W1545616820 hasConcept C21880701 @default.
• W1545616820 hasConcept C3019696108 @default.
• W1545616820 hasConceptScore W1545616820C127413603 @default.

• next