Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545676921> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1545676921 endingPage "110" @default.
- W1545676921 startingPage "107" @default.
- W1545676921 abstract "The effects of tilisolol hydrochloride, a new β-blocker, on the activation of the adenosine 5′-triphosphate (ATP)-sensitive K+ channel (KATP channel) has been investigated using the patch-clamp technique.In cell-attached patch configurations, 0·3 μM tilisolol hydrochloride significantly activated the KATP channel of cultured porcine coronary artery smooth muscle cells. In excised inside-out patch configurations, tilisolol hydrochloride activated the KATP channel in a concentration-dependent manner in the presence, but not the absence, of 100 μm adenosine 5′-diphosphate (ADP). In the presence of 100 μM ADP, the open probabilities of the KATP channels were significantly increased from 0·032±0·006 to 1·314±1·162 (n = 4, P < 0·05) by addition of 10 μM tilisolol hydrochloride. We also studied this ADP-dependency of the K+-channel openers, nicorandil, levcromakalim and pinacidil. Like tilisolol hydrochloride, nicorandil also activated the KATP channel in the presence, but not the absence, of ADP. Levcromakalim and pinacidil activated the KATP channel even without ADP.The finding that tilisolol hydrochloride required ADP to activate the KATP channel in excised inside-out patch configurations suggests that tilisolol hydrochloride is an ADP-dependent KATP-channel opener like nicorandil, and unlike levcromakalim and pinacidil. Thus, KATP-channel openers may be distinguished by their dependency on ADP in activating the KATP channel." @default.
- W1545676921 created "2016-06-24" @default.
- W1545676921 creator A5038923350 @default.
- W1545676921 creator A5040125343 @default.
- W1545676921 creator A5058999827 @default.
- W1545676921 creator A5066645932 @default.
- W1545676921 date "1996-02-01" @default.
- W1545676921 modified "2023-09-24" @default.
- W1545676921 title "ADP-dependent Activation of ATP-sensitive K+ Channels in Cultured Porcine Coronary Artery Smooth Muscle Cells by Tilisolol Hydrochloride" @default.
- W1545676921 doi "https://doi.org/10.1111/j.2042-7158.1996.tb00569.x" @default.
- W1545676921 hasPublicationYear "1996" @default.
- W1545676921 type Work @default.
- W1545676921 sameAs 1545676921 @default.
- W1545676921 citedByCount "0" @default.
- W1545676921 crossrefType "journal-article" @default.
- W1545676921 hasAuthorship W1545676921A5038923350 @default.
- W1545676921 hasAuthorship W1545676921A5040125343 @default.
- W1545676921 hasAuthorship W1545676921A5058999827 @default.
- W1545676921 hasAuthorship W1545676921A5066645932 @default.
- W1545676921 hasConcept C12554922 @default.
- W1545676921 hasConcept C134018914 @default.
- W1545676921 hasConcept C147944092 @default.
- W1545676921 hasConcept C170493617 @default.
- W1545676921 hasConcept C185592680 @default.
- W1545676921 hasConcept C2775984225 @default.
- W1545676921 hasConcept C2776309818 @default.
- W1545676921 hasConcept C2776460385 @default.
- W1545676921 hasConcept C2776991684 @default.
- W1545676921 hasConcept C2778902376 @default.
- W1545676921 hasConcept C2779768347 @default.
- W1545676921 hasConcept C42219234 @default.
- W1545676921 hasConcept C55493867 @default.
- W1545676921 hasConcept C555293320 @default.
- W1545676921 hasConcept C71924100 @default.
- W1545676921 hasConcept C83743174 @default.
- W1545676921 hasConcept C86803240 @default.
- W1545676921 hasConcept C98274493 @default.
- W1545676921 hasConceptScore W1545676921C12554922 @default.
- W1545676921 hasConceptScore W1545676921C134018914 @default.
- W1545676921 hasConceptScore W1545676921C147944092 @default.
- W1545676921 hasConceptScore W1545676921C170493617 @default.
- W1545676921 hasConceptScore W1545676921C185592680 @default.
- W1545676921 hasConceptScore W1545676921C2775984225 @default.
- W1545676921 hasConceptScore W1545676921C2776309818 @default.
- W1545676921 hasConceptScore W1545676921C2776460385 @default.
- W1545676921 hasConceptScore W1545676921C2776991684 @default.
- W1545676921 hasConceptScore W1545676921C2778902376 @default.
- W1545676921 hasConceptScore W1545676921C2779768347 @default.
- W1545676921 hasConceptScore W1545676921C42219234 @default.
- W1545676921 hasConceptScore W1545676921C55493867 @default.
- W1545676921 hasConceptScore W1545676921C555293320 @default.
- W1545676921 hasConceptScore W1545676921C71924100 @default.
- W1545676921 hasConceptScore W1545676921C83743174 @default.
- W1545676921 hasConceptScore W1545676921C86803240 @default.
- W1545676921 hasConceptScore W1545676921C98274493 @default.
- W1545676921 hasIssue "2" @default.
- W1545676921 hasLocation W15456769211 @default.
- W1545676921 hasOpenAccess W1545676921 @default.
- W1545676921 hasPrimaryLocation W15456769211 @default.
- W1545676921 hasRelatedWork W1144877369 @default.
- W1545676921 hasRelatedWork W1555094340 @default.
- W1545676921 hasRelatedWork W1945499848 @default.
- W1545676921 hasRelatedWork W1978361293 @default.
- W1545676921 hasRelatedWork W1980629110 @default.
- W1545676921 hasRelatedWork W1989929358 @default.
- W1545676921 hasRelatedWork W1990709131 @default.
- W1545676921 hasRelatedWork W2022417072 @default.
- W1545676921 hasRelatedWork W2028827729 @default.
- W1545676921 hasRelatedWork W2060349900 @default.
- W1545676921 hasRelatedWork W2073761794 @default.
- W1545676921 hasRelatedWork W2079353263 @default.
- W1545676921 hasRelatedWork W2092763875 @default.
- W1545676921 hasRelatedWork W2150353959 @default.
- W1545676921 hasRelatedWork W2324748326 @default.
- W1545676921 hasRelatedWork W2380868273 @default.
- W1545676921 hasRelatedWork W2417752080 @default.
- W1545676921 hasRelatedWork W2520588077 @default.
- W1545676921 hasRelatedWork W3037089012 @default.
- W1545676921 hasRelatedWork W3016493638 @default.
- W1545676921 hasVolume "2" @default.
- W1545676921 isParatext "false" @default.
- W1545676921 isRetracted "false" @default.
- W1545676921 magId "1545676921" @default.
- W1545676921 workType "article" @default.