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• W1545709739 abstract "Wang, Chunmin Ph.D., Purdue University, December 2013. Store-operated Ca Entry and Its Function During Fertilization in Porcine Eggs . Major Professor: Zoltan Machaty. In a variety of mammalian cells, the depletion of intracellular Ca stores leads to Ca influx across the plasma membrane though a process known as store-operated Ca entry. It not only plays a critical role in the replenishment of the Ca stores but it is also responsible for the maintenance of long-lasting high intracellular Ca levels and sustaining repetitive Ca oscillations. During fertilization a Ca signal, which can take the form of a single or multiple Ca elevations (depending on the species) is the universal trigger for the egg-to-embryo transition. For sustaining the train of Ca spikes an influx of Ca across the plasma membrane is an absolute pre-requisite. However, despite its significance little is known about the mechanism that mediates Ca influx at fertilization. Previously we have shown that STIM1, a key component of the store-operated calcium entry pathway plays an important role in regulating the oscillatory Ca signal during porcine fertilization. In the present study we dissected the mechanism that maintains the repetitive fertilization Ca signal. Using gadolinium (Gd) we specifically inhibited Ca channels gated by the filling status of the intracellular Ca stores in order to better understand this critical signaling cascade. We found that in control eggs store depletion in Ca -free medium followed by Ca add-back triggered an elevation in the cytosolic Ca levels indicating store-operated Ca entry. This Ca influx was completely blocked in gadolinium pre-treated oocytes. Furthermore, the sperm-induced Ca oscillations were also abolished by the addition of gadolinium and 2-APB, a modulator of store-operated Ca entry also disrupted the fertilization Ca signal." @default.
• W1545709739 created "2016-06-24" @default.
• W1545709739 creator A5076437405 @default.
• W1545709739 date "2013-01-01" @default.
• W1545709739 modified "2023-09-27" @default.
• W1545709739 title "Store-operated Ca2+ entry and its function during fertilization in porcine eggs" @default.
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• W1545709739 cites W1573590097 @default.
• W1545709739 cites W1586649084 @default.
• W1545709739 cites W1597385852 @default.
• W1545709739 cites W1784820495 @default.
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• W1545709739 cites W1970744548 @default.
• W1545709739 cites W1975987121 @default.
• W1545709739 cites W1978530652 @default.
• W1545709739 cites W1979573280 @default.
• W1545709739 cites W1986554781 @default.
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• W1545709739 cites W1993182344 @default.
• W1545709739 cites W1993886090 @default.
• W1545709739 cites W1998606603 @default.
• W1545709739 cites W2000058300 @default.
• W1545709739 cites W2006651175 @default.
• W1545709739 cites W2008245136 @default.
• W1545709739 cites W2009298563 @default.
• W1545709739 cites W2012471725 @default.
• W1545709739 cites W2012641207 @default.
• W1545709739 cites W2016348702 @default.
• W1545709739 cites W2019817696 @default.
• W1545709739 cites W2020708758 @default.
• W1545709739 cites W2021090089 @default.
• W1545709739 cites W2025775682 @default.
• W1545709739 cites W2029301182 @default.
• W1545709739 cites W2033620401 @default.
• W1545709739 cites W2034873828 @default.
• W1545709739 cites W2036664585 @default.
• W1545709739 cites W2037289981 @default.
• W1545709739 cites W2040742434 @default.
• W1545709739 cites W2040884361 @default.
• W1545709739 cites W2044645062 @default.
• W1545709739 cites W2046487211 @default.
• W1545709739 cites W2047716374 @default.
• W1545709739 cites W2053766825 @default.
• W1545709739 cites W2055512050 @default.
• W1545709739 cites W2056042025 @default.
• W1545709739 cites W2056768252 @default.
• W1545709739 cites W2057889296 @default.
• W1545709739 cites W2063048358 @default.
• W1545709739 cites W2064541275 @default.
• W1545709739 cites W2070640442 @default.
• W1545709739 cites W2070832223 @default.
• W1545709739 cites W2071335431 @default.
• W1545709739 cites W2073053635 @default.
• W1545709739 cites W2073513198 @default.
• W1545709739 cites W2073529464 @default.
• W1545709739 cites W2075305901 @default.
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• W1545709739 cites W2079055998 @default.
• W1545709739 cites W2087588584 @default.
• W1545709739 cites W2090018138 @default.
• W1545709739 cites W2097939257 @default.
• W1545709739 cites W2098936081 @default.
• W1545709739 cites W2099142372 @default.
• W1545709739 cites W2101586949 @default.
• W1545709739 cites W2107277218 @default.
• W1545709739 cites W2113950149 @default.
• W1545709739 cites W2114366598 @default.
• W1545709739 cites W2118478876 @default.
• W1545709739 cites W2118988881 @default.
• W1545709739 cites W2127739281 @default.
• W1545709739 cites W2128270335 @default.
• W1545709739 cites W2132204920 @default.
• W1545709739 cites W2135002279 @default.
• W1545709739 cites W2137258759 @default.
• W1545709739 cites W2146341872 @default.
• W1545709739 cites W2146685564 @default.
• W1545709739 cites W2148890218 @default.
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• W1545709739 cites W2157269171 @default.
• W1545709739 cites W2157275644 @default.
• W1545709739 cites W2163789582 @default.
• W1545709739 cites W2187851764 @default.
• W1545709739 cites W2345060814 @default.
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• W1545709739 cites W2414393060 @default.
• W1545709739 cites W2621490319 @default.
• W1545709739 cites W1971633031 @default.
• W1545709739 cites W1991132408 @default.
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