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- W154577290 abstract "Changes in the extracellular concentration of glutamate in the brain ([Glu]e) were monitored continously by an enzyme-amperometric technique employing a dialysis electrode during ischemia caused by isolation of the brain tissue in rats and human patients. In the rat (n = 10), the dialysis electrode was placed in the frontal cortex and the frontal lobe was transected. A transient sharp increase in [Glu]e was frequently observed during the transection. A biphasic elevation (a rapid increase followed by a slowly continuing increase) subsequently occurred with a latent period of 1–3 min after the transection of the rat frontal lobe. In patients (n = 7), the dialysis electrode was placed in tumor-free cortical areas which were planned to be resected together with gliomas. Progressive increases in [Glu]e were observed in all of the patients as the isolation of the brain tissue progressed. A biphasic increase, similar to that seen in the rat, was identified in 2 patients in whom the cortical area surrounding the dialysis electrode was rapidly isolated. The present enzymeamperometric technique employing a dialysis electrode appears to be useful for detecting the occurrence of potentially harmful ischemia and for securing minimal metabolic stress caused during various surgical manipulations." @default.
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- W154577290 date "1999-01-01" @default.
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- W154577290 title "Intraoperative Enzyme-Amperometric Monitoring of Extracellular Glutamate Concentration with a Dialysis Electrode in Ischemic Human Brain" @default.
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- W154577290 doi "https://doi.org/10.1007/978-3-7091-6415-0_3" @default.
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