Matches in SemOpenAlex for { <https://semopenalex.org/work/W1545913212> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1545913212 endingPage "167" @default.
- W1545913212 startingPage "161" @default.
- W1545913212 abstract "γ-Hydroxybutyric acid (GHB) produces a constellation of EEG and behavioral changes when given to animals, which represent an experimental model of generalized absence seizures. γ-Butyrolactone (GBL), the prodrug of GHB, produces these changes more rapidly and consistently than GHB, such that the rat treated with GBL is a more reproducible and predictable model of absence seizures. The hypothesis that the epileptogenic effects of GBL are due solely to its conversion to GHB was tested. The regional concentration of both compounds in brain was determined in time-course and dose-response studies, as well as at the onset of EEG changes, induced by both GHB and GBL. Also, the EEG and behavioral effects of both drugs were ascertained after intrathalamic injection in the rat. γ-Butyrolactone produced a rapid onset of bilaterally synchronous spike and wave discharges in the rat, which correlated with a rapid appearance of GHB in brain in the GBL-treated animals. In the GHB-treated animals, EEG changes occurred 20 min after administration of GHB when levels of GHB in the brain were peaking. The threshold concentration of GHB in brain for EEG changes, in both GHB-and GBL-treated animals was 240 × 10−6M. The concentration of GBL in brain peaked 1 min after administration of GBL and fell rapidly to undetectable levels within 5 min. Bilateral injection of GHB into thalamus resulted in a brief burst of spike and wave discharges, while GBL, administered into the thalamus, had no effect. The use of GBL as a prodrug for GHB in this model of generalized absence seizures is valid, since GBL itself was inactive." @default.
- W1545913212 created "2016-06-24" @default.
- W1545913212 creator A5026618924 @default.
- W1545913212 date "1991-02-01" @default.
- W1545913212 modified "2023-09-23" @default.
- W1545913212 title "The γ-hydroxybutyrate model of absence seizures: correlation of regional brain levels of γ-hydroxybutyric acid and γ-butyrolactone with spike wave discharges" @default.
- W1545913212 cites W1500443701 @default.
- W1545913212 cites W1684853394 @default.
- W1545913212 cites W1906557722 @default.
- W1545913212 cites W1974383888 @default.
- W1545913212 cites W1977880829 @default.
- W1545913212 cites W1995316734 @default.
- W1545913212 cites W2002956716 @default.
- W1545913212 cites W2006880950 @default.
- W1545913212 cites W2015743538 @default.
- W1545913212 cites W2016250406 @default.
- W1545913212 cites W2016982053 @default.
- W1545913212 cites W2018430265 @default.
- W1545913212 cites W2032310869 @default.
- W1545913212 cites W2041909724 @default.
- W1545913212 cites W2050402152 @default.
- W1545913212 cites W2059969175 @default.
- W1545913212 cites W2059980819 @default.
- W1545913212 cites W2064266467 @default.
- W1545913212 cites W2067945018 @default.
- W1545913212 cites W2073274241 @default.
- W1545913212 cites W2087584370 @default.
- W1545913212 cites W2088035323 @default.
- W1545913212 cites W2136514333 @default.
- W1545913212 cites W2139578829 @default.
- W1545913212 cites W2163815564 @default.
- W1545913212 cites W2325839980 @default.
- W1545913212 cites W2401958828 @default.
- W1545913212 cites W2409799298 @default.
- W1545913212 cites W2416099281 @default.
- W1545913212 doi "https://doi.org/10.1016/0028-3908(91)90199-l" @default.
- W1545913212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2030821" @default.
- W1545913212 hasPublicationYear "1991" @default.
- W1545913212 type Work @default.
- W1545913212 sameAs 1545913212 @default.
- W1545913212 citedByCount "105" @default.
- W1545913212 countsByYear W15459132122012 @default.
- W1545913212 countsByYear W15459132122013 @default.
- W1545913212 countsByYear W15459132122014 @default.
- W1545913212 countsByYear W15459132122015 @default.
- W1545913212 countsByYear W15459132122016 @default.
- W1545913212 countsByYear W15459132122017 @default.
- W1545913212 countsByYear W15459132122018 @default.
- W1545913212 countsByYear W15459132122019 @default.
- W1545913212 countsByYear W15459132122021 @default.
- W1545913212 crossrefType "journal-article" @default.
- W1545913212 hasAuthorship W1545913212A5026618924 @default.
- W1545913212 hasConcept C169760540 @default.
- W1545913212 hasConcept C185592680 @default.
- W1545913212 hasConcept C2779246727 @default.
- W1545913212 hasConcept C2911064607 @default.
- W1545913212 hasConcept C42219234 @default.
- W1545913212 hasConcept C522805319 @default.
- W1545913212 hasConcept C71924100 @default.
- W1545913212 hasConcept C73745247 @default.
- W1545913212 hasConcept C86803240 @default.
- W1545913212 hasConcept C98274493 @default.
- W1545913212 hasConceptScore W1545913212C169760540 @default.
- W1545913212 hasConceptScore W1545913212C185592680 @default.
- W1545913212 hasConceptScore W1545913212C2779246727 @default.
- W1545913212 hasConceptScore W1545913212C2911064607 @default.
- W1545913212 hasConceptScore W1545913212C42219234 @default.
- W1545913212 hasConceptScore W1545913212C522805319 @default.
- W1545913212 hasConceptScore W1545913212C71924100 @default.
- W1545913212 hasConceptScore W1545913212C73745247 @default.
- W1545913212 hasConceptScore W1545913212C86803240 @default.
- W1545913212 hasConceptScore W1545913212C98274493 @default.
- W1545913212 hasIssue "2" @default.
- W1545913212 hasLocation W15459132121 @default.
- W1545913212 hasLocation W15459132122 @default.
- W1545913212 hasOpenAccess W1545913212 @default.
- W1545913212 hasPrimaryLocation W15459132121 @default.
- W1545913212 hasRelatedWork W1481458145 @default.
- W1545913212 hasRelatedWork W1551603644 @default.
- W1545913212 hasRelatedWork W1643357760 @default.
- W1545913212 hasRelatedWork W1991677951 @default.
- W1545913212 hasRelatedWork W2039175771 @default.
- W1545913212 hasRelatedWork W2087744263 @default.
- W1545913212 hasRelatedWork W2118849533 @default.
- W1545913212 hasRelatedWork W2216634193 @default.
- W1545913212 hasRelatedWork W2990368499 @default.
- W1545913212 hasRelatedWork W3207164704 @default.
- W1545913212 hasVolume "30" @default.
- W1545913212 isParatext "false" @default.
- W1545913212 isRetracted "false" @default.
- W1545913212 magId "1545913212" @default.
- W1545913212 workType "article" @default.