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• W1545947145 abstract "Publisher Summary This chapter focuses on the progress made toward the identification of potent and effective inhibitors of hepatitis C virus (HCV) that do not target the key enzymes NS3 protease and NS5B polymerase. The HCV NS3 protease and NS5B RNA-dependent RNA polymerase were inevitably the initial targets of focus because these enzymes were readily recapitulated functionally using biochemical assays, an effort considerably facilitated by the solving of X-ray crystallographic structures that informed structure-based drug design campaigns. The genomic arrangement of HCV is depicted in the chapter. The viral genome is translated as a single polyprotein that is cleaved by a combination of host cell proteases and the viral proteases NS2 and NS3. All viral proteins are plausible targets, and since many play multiple roles in replication, temporal selectivity based on unique protein function at different stages of the virus life cycle may be possible. Inhibitors of HCV NS5A are the most clinically advanced and appear to offer promise both as adjunct therapy and in combination with mechanistically complementary direct-acting antiviral agents." @default.
• W1545947145 created "2016-06-24" @default.
• W1545947145 creator A5030908223 @default.
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• W1545947145 date "2011-01-01" @default.
• W1545947145 modified "2023-09-24" @default.
• W1545947145 title "Hepatitis C Virus—Progress Toward Inhibiting the Nonenzymatic Viral Proteins" @default.
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• W1545947145 doi "https://doi.org/10.1016/b978-0-12-386009-5.00011-4" @default.
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