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• W1546080548 endingPage "3945" @default.
• W1546080548 startingPage "3941" @default.
• W1546080548 abstract "Abstract Both macrophages and activated CD4+ T cells can be productively infected by HIV-1, and both cell types express MHC class II molecules. Expression of MHC class II proteins in these cells is regulated by a specific transcriptional coactivator, the class II transactivator (CIITA). In this study, we report for the first time that CIITA expression profoundly influences HIV-1 replication. Stable expression of CIITA in Jurkat cells markedly increased 1) HIV-1 replication as assessed by the p24 Ag production and 2) luciferase expression after transfection with full-length provirus or long terminal repeat constructs. Similarly, transient expression of CIITA increased provirus expression as well as long terminal repeat promoter activity in 293 and HeLa-T4 cells. In contrast, mutant forms of CIITA did not increase HIV-1 expression. This study shows that expression of CIITA increases HIV-1 replication through a transcriptional mechanism." @default.
• W1546080548 created "2016-06-24" @default.
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• W1546080548 date "2000-04-15" @default.
• W1546080548 modified "2023-10-18" @default.
• W1546080548 title "Cutting Edge: Activation of HIV-1 Transcription by the MHC Class II Transactivator" @default.
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• W1546080548 doi "https://doi.org/10.4049/jimmunol.164.8.3941" @default.
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