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- W1546092225 endingPage "485" @default.
- W1546092225 startingPage "465" @default.
- W1546092225 abstract "Abstract Cell volume homeostasis and its fine‐tuning to the specific physiological context at any given moment are processes fundamental to normal cell function. The understanding of cell volume regulation owes much to August Krogh, yet has advanced greatly over the last decades. In this review, we outline the historical context of studies of cell volume regulation, focusing on the lineage started by Krogh, Bodil Schmidt‐Nielsen, Hans‐Henrik Ussing, and their students. The early work was focused on understanding the functional behaviour, kinetics and thermodynamics of the volume‐regulatory ion transport mechanisms. Later work addressed the mechanisms through which cellular signalling pathways regulate the volume regulatory effectors or flux pathways. These studies were facilitated by the molecular identification of most of the relevant channels and transporters, and more recently also by the increased understanding of their structures. Finally, much current research in the field focuses on the most up‐ and downstream components of these paths: how cells sense changes in cell volume, and how cell volume changes in turn regulate cell function under physiological and pathophysiological conditions." @default.
- W1546092225 created "2016-06-24" @default.
- W1546092225 creator A5015579145 @default.
- W1546092225 creator A5022507661 @default.
- W1546092225 date "2010-11-09" @default.
- W1546092225 modified "2023-09-25" @default.
- W1546092225 title "Cell volume homeostatic mechanisms: effectors and signalling pathways" @default.
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