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- W1546269915 abstract "Correspondence: Dr. R. Carmena. Departamento de Medicina. Universidad de Valencia. Avda. Blasco Ibanez, 17. 46010 Valencia. Espana. E-mail: carmena@uv.es Type 2 diabetes carries an elevated cardiovascular risk. A significant component of such risk can be attributed to diabetic dyslipidemia, a cluster of plasma lipid and lipoprotein abnormalities that are metabolically interrelated. Its main characteristics are elevated triglycerides, lowered high-density lipoproteins (HDL), and raised small, dense low-density lipoproteins (LDL) that are referred to as the “atherogenic lipid triad.” Diabetic dyslipidemia is associated with insulin resistance, visceral obesity and liver fat content. Insulin resistance is related to excessive flux of substrates (ie, free fatty acids, FFA) for very low density lipoproteins (VLDL) assembly in the liver, as well as the upregulation of the machinery generating large VLDL1 particles in excess. The recognition that the elevation of large VLDL1 particles initiates a sequence of events leading to the formation of small dense LDL and HDL species has focused the assembly of VLDL particles on the spotlight as a potential culprit of diabetic dyslipidemia. Other components of the atherogenic lipid profile are elevated apoB, prolonged postprandial lipemia and accumulation of remnant particles in the circulation. Different prospective trials with statins have proven effective in the treatment of diabetic dyslipidemia but the residual cardiovascular risk remains high. Future trials with new lipid-lowering and antidiabetic agents will hopefully allow more targeted treatment of lipid disorders and postprandial lipemia in type 2 diabetic subjects." @default.
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- W1546269915 date "2008-06-05" @default.
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- W1546269915 title "High Risk of Lipoprotein Dysfunction in Type 2 Diabetes Mellitus" @default.
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