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- W1546588595 abstract "Abstract 1,2-Anhydro-d-mannitol-6-P rapidly inactivates phosphoglucose isomerase and becomes covalently bound in ester linkage to a glutamate residue. Protection by a competitive inhibitor, saturation kinetics, and strict stoichiometry of alkylation indicate reaction at the active site only. The Vmax of inactivation shows a pH dependence similar to the catalytic Vmax, pK1 = 6.3, pK2 = 9.9. 1,2-Anhydro-l-iditol-6-P and 1,2-anhydro-d-glucitol-6-P also inactivate, possibly at the same residue, but at only 2% of the rate of the mannitol compound." @default.
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- W1546588595 date "1973-03-01" @default.
- W1546588595 modified "2023-10-11" @default.
- W1546588595 title "Affinity Labeling of Phosphoglucose Isomerase by 1,2-Anhydrohexitol-6-phosphates" @default.
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- W1546588595 doi "https://doi.org/10.1016/s0021-9258(19)44209-9" @default.
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