Matches in SemOpenAlex for { <https://semopenalex.org/work/W1546656144> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1546656144 endingPage "9" @default.
- W1546656144 startingPage "1104" @default.
- W1546656144 abstract "Murine embryonal carcinoma (EC) cells were characterized with respect to their ability to metabolize the polycyclic aromatic hydrocarbon, benzo(a)pyrene [B(a)P]. The extent of metabolic activation varied more than 100-fold among the teratocarcinoma-derived cell lines examined. This difference in metabolic activity was correlated with an increase in the formation of specific metabolites that were identified by high-pressure liquid chromatography. Maximal in vitro formation of water-soluble products occurred 24 hr after the addition of [3H]B(a)P to the EC cells. Long-term incubation of EC cells with [3H]B(a)P indicated that, within the initial 24 hr, 2.3% of the input had been taken up by the cells. Subcellular analysis of the distribution of radioactivity indicated that 70 to 80% of intracellular radioactivity was associated with isolated nuclei. Therefore, the intranuclear metabolites of B(a)P were also analyzed by high-pressure liquid chromatography. Embryonal carcinoma cell lines OC15S1 and C86S1 showed significant in vitro toxic effects to B(a)P over a concentration range of 0.05 to 0.3 microgram/ml, whereas F9 and PC13 were resistant to concentrations of B(a)P up to 5 microgram/ml. Equally resistant to B(a)P was the PYS cell line, a differentiated cell type derived from EC cells. Cytotoxicity was related to the extent of metabolic activation of parent compound." @default.
- W1546656144 created "2016-06-24" @default.
- W1546656144 creator A5034997559 @default.
- W1546656144 creator A5063057918 @default.
- W1546656144 date "1981-03-01" @default.
- W1546656144 modified "2023-09-23" @default.
- W1546656144 title "Metabolism of benzo(a)pyrene by murine embryonal carcinoma cells." @default.
- W1546656144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7459855" @default.
- W1546656144 hasPublicationYear "1981" @default.
- W1546656144 type Work @default.
- W1546656144 sameAs 1546656144 @default.
- W1546656144 citedByCount "2" @default.
- W1546656144 crossrefType "journal-article" @default.
- W1546656144 hasAuthorship W1546656144A5034997559 @default.
- W1546656144 hasAuthorship W1546656144A5063057918 @default.
- W1546656144 hasConcept C104317684 @default.
- W1546656144 hasConcept C109316439 @default.
- W1546656144 hasConcept C114246631 @default.
- W1546656144 hasConcept C148738053 @default.
- W1546656144 hasConcept C153911025 @default.
- W1546656144 hasConcept C178790620 @default.
- W1546656144 hasConcept C185592680 @default.
- W1546656144 hasConcept C202751555 @default.
- W1546656144 hasConcept C2777538855 @default.
- W1546656144 hasConcept C2778951431 @default.
- W1546656144 hasConcept C2908788973 @default.
- W1546656144 hasConcept C51296783 @default.
- W1546656144 hasConcept C54355233 @default.
- W1546656144 hasConcept C55493867 @default.
- W1546656144 hasConcept C62231903 @default.
- W1546656144 hasConcept C79879829 @default.
- W1546656144 hasConcept C81885089 @default.
- W1546656144 hasConcept C86803240 @default.
- W1546656144 hasConceptScore W1546656144C104317684 @default.
- W1546656144 hasConceptScore W1546656144C109316439 @default.
- W1546656144 hasConceptScore W1546656144C114246631 @default.
- W1546656144 hasConceptScore W1546656144C148738053 @default.
- W1546656144 hasConceptScore W1546656144C153911025 @default.
- W1546656144 hasConceptScore W1546656144C178790620 @default.
- W1546656144 hasConceptScore W1546656144C185592680 @default.
- W1546656144 hasConceptScore W1546656144C202751555 @default.
- W1546656144 hasConceptScore W1546656144C2777538855 @default.
- W1546656144 hasConceptScore W1546656144C2778951431 @default.
- W1546656144 hasConceptScore W1546656144C2908788973 @default.
- W1546656144 hasConceptScore W1546656144C51296783 @default.
- W1546656144 hasConceptScore W1546656144C54355233 @default.
- W1546656144 hasConceptScore W1546656144C55493867 @default.
- W1546656144 hasConceptScore W1546656144C62231903 @default.
- W1546656144 hasConceptScore W1546656144C79879829 @default.
- W1546656144 hasConceptScore W1546656144C81885089 @default.
- W1546656144 hasConceptScore W1546656144C86803240 @default.
- W1546656144 hasIssue "3" @default.
- W1546656144 hasLocation W15466561441 @default.
- W1546656144 hasOpenAccess W1546656144 @default.
- W1546656144 hasPrimaryLocation W15466561441 @default.
- W1546656144 hasRelatedWork W1544885936 @default.
- W1546656144 hasRelatedWork W1546656144 @default.
- W1546656144 hasRelatedWork W1975358980 @default.
- W1546656144 hasRelatedWork W2017214690 @default.
- W1546656144 hasRelatedWork W2022425138 @default.
- W1546656144 hasRelatedWork W2081952647 @default.
- W1546656144 hasRelatedWork W2087130802 @default.
- W1546656144 hasRelatedWork W2157451819 @default.
- W1546656144 hasRelatedWork W2412246493 @default.
- W1546656144 hasRelatedWork W99826116 @default.
- W1546656144 hasVolume "41" @default.
- W1546656144 isParatext "false" @default.
- W1546656144 isRetracted "false" @default.
- W1546656144 magId "1546656144" @default.
- W1546656144 workType "article" @default.