Matches in SemOpenAlex for { <https://semopenalex.org/work/W1546721359> ?p ?o ?g. }
- W1546721359 endingPage "1193" @default.
- W1546721359 startingPage "1177" @default.
- W1546721359 abstract "Neuronal nitric oxide synthase (nNOS) expression can be regulated under natural or experimental conditions. This work aims at elucidating whether the expression of nNOS or its related NADPH-diaphorase (ND) activity are modified by manipulation of the normal inputs to neurons. We used the olfactory bulbs from two mouse strains, BALB and CD1, because they show divergences in their synapse patterns, and these differences affect periglomerular cells, interneurons expressing tyrosine hydroxylase or nNOS/ND. The olfactory inputs to these neurons can be disrupted by inhalation of methyl bromide. The effect of this gas on olfactory axons, as well as the synaptic features in both mouse strains, were studied using electron microscopy. The changes in expression were analysed qualitatively and quantitatively at different times after lesion to nine topographical regions of the olfactory bulb. Methyl bromide inhalation induced a degeneration of olfactory axons in both strains, but had different effects on the expression of nNOS/ND and tyrosine hydroxylase. In BALB mice, where periglomerular cells do not receive direct inputs from olfactory axons, no changes were detected in tyrosine hydroxylase or in ND expression. In CD1 periglomerular cells, where olfactory axons establish direct synapses, a significant down-regulation of both markers was observed. These changes were observed differentially across the olfactory bulb, being more pronounced in rostral regions and more acute for ND than for tyrosine hydroxylase. Our results indicate that the synaptic inputs influence the expression of ND activity related to nNOS and that the activation of the enzyme is more severely affected than its protein expression." @default.
- W1546721359 created "2016-06-24" @default.
- W1546721359 creator A5019363793 @default.
- W1546721359 creator A5037404471 @default.
- W1546721359 creator A5043414758 @default.
- W1546721359 creator A5071510284 @default.
- W1546721359 creator A5072410159 @default.
- W1546721359 creator A5074024292 @default.
- W1546721359 date "2000-04-01" @default.
- W1546721359 modified "2023-10-09" @default.
- W1546721359 title "Expression of neuronal nitric oxide synthase/NADPH-diaphorase during olfactory deafferentation and regeneration" @default.
- W1546721359 cites W1553305230 @default.
- W1546721359 cites W1580172964 @default.
- W1546721359 cites W1636573694 @default.
- W1546721359 cites W1793673261 @default.
- W1546721359 cites W195147556 @default.
- W1546721359 cites W1961943243 @default.
- W1546721359 cites W1969045051 @default.
- W1546721359 cites W1973042031 @default.
- W1546721359 cites W1974618036 @default.
- W1546721359 cites W1975552692 @default.
- W1546721359 cites W1977740519 @default.
- W1546721359 cites W1977923059 @default.
- W1546721359 cites W1984527988 @default.
- W1546721359 cites W1986326050 @default.
- W1546721359 cites W1987803938 @default.
- W1546721359 cites W1988411375 @default.
- W1546721359 cites W1991345860 @default.
- W1546721359 cites W1991457276 @default.
- W1546721359 cites W1996948567 @default.
- W1546721359 cites W2000258847 @default.
- W1546721359 cites W2001383967 @default.
- W1546721359 cites W2002059158 @default.
- W1546721359 cites W2005209827 @default.
- W1546721359 cites W2006858963 @default.
- W1546721359 cites W2007126422 @default.
- W1546721359 cites W2012720486 @default.
- W1546721359 cites W2013098977 @default.
- W1546721359 cites W2013935916 @default.
- W1546721359 cites W2017230689 @default.
- W1546721359 cites W2028468118 @default.
- W1546721359 cites W2030265650 @default.
- W1546721359 cites W2034756100 @default.
- W1546721359 cites W2038507265 @default.
- W1546721359 cites W2039905847 @default.
- W1546721359 cites W2040199005 @default.
- W1546721359 cites W2044195886 @default.
- W1546721359 cites W2049490437 @default.
- W1546721359 cites W2053262436 @default.
- W1546721359 cites W2056455961 @default.
- W1546721359 cites W2058495363 @default.
- W1546721359 cites W2058900600 @default.
- W1546721359 cites W2059379142 @default.
- W1546721359 cites W2059640915 @default.
- W1546721359 cites W2061051147 @default.
- W1546721359 cites W2065384973 @default.
- W1546721359 cites W2066366316 @default.
- W1546721359 cites W2075620680 @default.
- W1546721359 cites W2076975822 @default.
- W1546721359 cites W2082961737 @default.
- W1546721359 cites W2089037071 @default.
- W1546721359 cites W2090685652 @default.
- W1546721359 cites W2091007692 @default.
- W1546721359 cites W2093048200 @default.
- W1546721359 cites W2094775201 @default.
- W1546721359 cites W2095109063 @default.
- W1546721359 cites W2107849357 @default.
- W1546721359 cites W2111919302 @default.
- W1546721359 cites W2120339303 @default.
- W1546721359 cites W2122305954 @default.
- W1546721359 cites W2164319707 @default.
- W1546721359 cites W2313326603 @default.
- W1546721359 cites W2313879889 @default.
- W1546721359 cites W2336763845 @default.
- W1546721359 cites W4252331976 @default.
- W1546721359 doi "https://doi.org/10.1046/j.1460-9568.2000.00003.x" @default.
- W1546721359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10762349" @default.
- W1546721359 hasPublicationYear "2000" @default.
- W1546721359 type Work @default.
- W1546721359 sameAs 1546721359 @default.
- W1546721359 citedByCount "35" @default.
- W1546721359 countsByYear W15467213592012 @default.
- W1546721359 countsByYear W15467213592013 @default.
- W1546721359 countsByYear W15467213592014 @default.
- W1546721359 countsByYear W15467213592019 @default.
- W1546721359 countsByYear W15467213592021 @default.
- W1546721359 crossrefType "journal-article" @default.
- W1546721359 hasAuthorship W1546721359A5019363793 @default.
- W1546721359 hasAuthorship W1546721359A5037404471 @default.
- W1546721359 hasAuthorship W1546721359A5043414758 @default.
- W1546721359 hasAuthorship W1546721359A5071510284 @default.
- W1546721359 hasAuthorship W1546721359A5072410159 @default.
- W1546721359 hasAuthorship W1546721359A5074024292 @default.
- W1546721359 hasConcept C127445978 @default.
- W1546721359 hasConcept C134018914 @default.
- W1546721359 hasConcept C159167319 @default.
- W1546721359 hasConcept C169760540 @default.
- W1546721359 hasConcept C185592680 @default.