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• W1546731760 abstract "9 INTRODUCTION 10 REVIEW OF THE LITERATURE 11 1. Cancer and genetic alterations 11 2. Chromosomal imbalances in cancer 12 2.1. Translocations and inversions 13 2.2. DNA copy number losses 13 2.3. Amplifications 14 2.4. Loss of heterozygosity 15 2.5. Uniparental disomy 16 3. Microarrays in the analysis of chromosomal imbalances 17 3.1. Array comparative genomic hybridization 17 3.2. Single-nucleotide polymorphism microarray analysis 19 4. Leukemia 22 4.1. Acute myeloid leukemia 22 4.1.1. Clinical characteristics and treatment of acute myeloid leukemia 22 4.1.2. Genetic alterations in acute myeloid leukemia 24 4.2. Chronic lymphocytic leukemia 27 4.2.1 Clinical characteristics and treatment of chronic lymphocytic leukemia 27 4.2.2. Genetic alterations in chronic lymphocytic leukemia 28 AIMS OF THE STUDY 31 MATERIALS AND METHODS 32 1. Specimens (I-IV) 32 1.1. Acute myeloid leukemia specimens 32 1.2. Chronic lymphocytic leukemia specimens 32 2. Complementary DNA array comparative genomic hybridization (I) 33 3. Oligonucleotide array comparative genomic hybridization (I-III) 33 4. Fluorescence in situ hybridization (I, II) 34 5. Gene expression (I) 35 6. Mutation analysis (II) 35 7. Loss of heterozygosity analysis with single-nucleotide polymorphism microarray (IV) ....... 35 RESULTS AND DISCUSSION 37 1. Characterization of 11q amplicons in acute myeloid leukemia (I) 37 2. Cryptic copy number changes in karyotypically normal acute myeloid leukemia (II) 40 3. Array comparative genomic hybridization in chronic lymphocytic leukemia (III) 42 4. Loss of heterozygosity in karyotypically normal acute myeloid leukemia (IV) 44 CONCLUSIONS 47 ACKNOWLEDGMENTS 50 REFERENCES 51" @default.
• W1546731760 created "2016-06-24" @default.
• W1546731760 creator A5023410148 @default.
• W1546731760 date "2009-12-11" @default.
• W1546731760 modified "2023-09-24" @default.
• W1546731760 title "GENOMIC MICROARRAYS IN CHROMOSOMAL ANALYSIS OF LEUKEMIA" @default.
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