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- W1546796065 abstract "This chapter provides an overview of different types of noninvasive imaging techniques that can be integrated into the central nervous system (CNS) drug discovery process. It discusses their impact from informing basic pharmacology to enabling critical decision-making in clinical evaluations of novel CNS therapeutics. The chapter primarily focuses on positron emission tomography (PET) and single photon emission computed tomography (SPECT) techniques. It presents an in-depth discussion of PET and SPECT in light of their multifaceted roles in the CNS drug discovery process, covering the following topics: basic principles of PET and SPECT; discovery process of PET and SPECT radiotracers; and applications in CNS drug discovery illustrated by specific literature examples. Recent advances in PET and SPECT tracer design and evaluation have shown promise in expediting the discovery of novel PET tracers to enable preclinical to clinical translation studies on neuro-targets." @default.
- W1546796065 created "2016-06-24" @default.
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- W1546796065 date "2015-01-02" @default.
- W1546796065 modified "2023-09-29" @default.
- W1546796065 title "Imaging Techniques for Central Nervous System (CNS) Drug Discovery" @default.
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- W1546796065 doi "https://doi.org/10.1002/9781118788523.ch17" @default.
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