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• W1546798247 abstract "Salmonella phage ϵ15 undergoes host-induced modification (HIM). Phage ϵ15[A] (phage ϵ15 grown on Salmonella anatum, called strain A) plates with low EOP on Salmonella butantan (=I-1) and vice versa. The restricting properties of the host cells on phage growth can be overcome by multiple infection (multiplicity activation) with restricted normal phage or with its temperature-sensitive mutant, but not with ultraviolet (UV)-inactivated phage. The phage-growth restricting factor is inactivated by a short exposure of cells to slight heat, and its synthesis is inhibited by chloramphenicol, but not by mitomycin C. Experiments with P32-labeled phages show that the DNA of the restricted phage is degraded rapidly after injection of the nonpermissive host, and that the degradation of injected DNA is prevented by heating the host cells prior to infection or by UV irradiation of the restricted phage." @default.
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• W1546798247 date "1964-02-01" @default.
• W1546798247 modified "2023-09-23" @default.
• W1546798247 title "On the mechanism of host-induced modification" @default.
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• W1546798247 doi "https://doi.org/10.1016/0042-6822(64)90005-4" @default.
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