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• W1546830995 abstract "The sequential functionalization of long-chain alkylamine controlled-pore glass (CPG) with a 3-hydroxypropyl-(2-cyanoethyl)thiophosphoryl linker and a dinucleoside phosphorotetrazolide leads to a uniquely engineered support for solid-phase synthesis. Unlike conventional succinylated-CPG supports, this support is designed to allow oligonucleotide deprotection and elimination of deprotection side-products to proceed without release of the oligonucleotide. When needed, the DNA oligonucleotide can be thermolytically released in 2 hr under essentially neutral conditions. The modified CPG support has been successfully employed in the synthesis of both native and fully phosphorothioated DNA 20-mers. On the basis of reversed-phase HPLC and electrophoretic analyses, the purity of the released oligonucleotides is comparable to that of identical oligonucleotides synthesized from succinylated-CPG supports, in terms of both shorter-than-full-length oligonucleotide contaminants and overall yields. The detailed preparation of DNA oligonucleotides conjugated with exemplary reporter or functional groups, either at the 3'-terminus or at both 3'- and 5'-termini, is also described." @default.
• W1546830995 created "2016-06-24" @default.
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• W1546830995 date "2008-12-01" @default.
• W1546830995 modified "2023-10-14" @default.
• W1546830995 title "Release of DNA Oligonucleotides and Their Conjugates from Controlled‐Pore Glass Under Thermolytic Conditions" @default.
• W1546830995 cites W1966419565 @default.
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• W1546830995 doi "https://doi.org/10.1002/0471142700.nc0317s35" @default.
• W1546830995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19085983" @default.
• W1546830995 hasPublicationYear "2008" @default.
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